ArticleFrontiers in bioengineering and biotechnology2022
3D printing polylactic acid polymer-bioactive glass loaded with bone cement for bone defect in weight-bearing area.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Recent advances in biomaterials for bone regeneration: Bridging innovation and clinical translation.Materials today. Bio · 2026Review
- Mechanical and biological properties of 3D printed bone tissue engineering scaffolds.Frontiers in bioengineering and biotechnology · 2025Review
- Kneadable dough-type hydrogel transforming from dynamic to rigid network to repair irregular bone defects.Bioactive materials · 2024Article
- Emerging Biomedical and Clinical Applications of 3D-Printed Poly(Lactic Acid)-Based Devices and Delivery Systems.Bioengineering (Basel, Switzerland) · 2024Review
- Synthetic biodegradable polymer materials in the repair of tumor-associated bone defects.Frontiers in bioengineering and biotechnology · 2023Review
- Hydrogels for 3D bioprinting in tissue engineering and regenerative medicine: Current progress and challenges.International journal of bioprinting · 2023Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
The treatment of bone defects in weight-bearing areas is mainly to transplant filling materials into the defect area, to provide immediate and strong support for weight-bearing. At present, the commonly used filling material is bone cement, which can only provide physical support without bone regeneration effect. The long-term stress at the interface may cause the loosening of bone cement. The ideal filling material should provide not only strong mechanical support but also promote bone regeneration. We introduce a 3D printing frame-filling structure in this study. The structure was printed with polylactic acid/bioactive glass as the frame, and bone cement as the filler. In this system, bone cement was used to provide immediate fixation, and the frame provided long-term fixation by promoting osteogenic induction and conduction between the interface. The results showed that the degradation of bioactive glass in the frame promoted osteogenic metabolism, induced M2 polarization of macrophages, and inhibited local inflammatory response. The
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