SynthesisAmerican journal of rhinology & allergy2023
Qualitative Olfactory Dysfunction and COVID-19: An Evidence-Based Review with Recommendations for the Clinician.
Synthesis in American journal of rhinology & allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- The assessment of qualitative olfactory dysfunction in COVID-19 patients: a systematic review of tools and their content validity.Frontiers in psychology · 2023Pooled it
- Alzheimer's early detection in post-acute COVID-19 syndrome: a systematic review and expert consensus on preclinical assessments.Frontiers in aging neuroscience · 2023Pooled it
- Review
- Self-reported cognitive and affective complaints associated with olfactory loss in an online survey of individuals with COVID-19.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Long COVID Symptom Management Through Self-Care and Nonprescription Treatment Options: A Narrative Review.International journal of environmental research and public health · 2025Review
- Trajectories of Coping With Persistent Smell and Taste Dysfunction After a Covid-19 Infection-A Qualitative Interview Study.Journal of advanced nursing · 2025Article
- Post COVID-19 and Long COVID Symptoms in Otorhinolaryngology-A Narrative Review.Journal of clinical medicine · 2025Review
- The mysterious sense of smell: evolution, historical perspectives, and neurological disorders.Frontiers in human neuroscience · 2025Review
- Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome.Scientific reports · 2024Article
- Taste and Smell Alterations (TSAs) in Cancer Patients.Diseases (Basel, Switzerland) · 2024Review
- Integrating the patient's voice into the research agenda for treatment of chemosensory disorders.Chemical senses · 2024Article
- Lavender Essential Oil Inhalation Improves Attentional Shifting and Accuracy: Evidence from Dynamic Changes of Cognitive Flexibility and Power Spectral Density of Electroencephalogram Signals.Journal of medical signals and sensors · 2024Article
- Long COVID-19-related and non-COVID-19 postviral olfactory dysfunction a comparative MRI study focusing on the olfactory cleft and bulbs.Frontiers in neurology · 2024Article
- Subjective versus Psychophysical Measures of Chemosensory Alterations following COVID-19.ORL; journal for oto-rhino-laryngology and its related specialties · 2024Article
- Review
- Article
- Factors Associated with Long COVID-19 in a French Multicentric Prospective Cohort Study.International journal of environmental research and public health · 2023Article
- Comparison of prevalence and evolution of COVID-19 olfactory disorders in patients infected by D614 (wild) and B.1.1.7. Alpha variant: a brief report.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Parosmia COVID-19 Related Treated by a Combination of Olfactory Training and Ultramicronized PEA-LUT: A Prospective Randomized Controlled Trial.Biomedicines · 2023Article
- Parosmia and altered taste in patients recovering from Covid 19.Clinical nutrition open science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundNearly 40% of patients who experience smell loss during SARS-CoV-2 infection may develop qualitative olfactory dysfunction, most commonly parosmia. Our evidence-based review summarizes the evolving literature and offers recommendations for the clinician on the management of patients experiencing parosmia associated with COVID-19.
methodsWe performed a systematic search using independent queries in PubMed, Embase, Ovid, and Cochrane databases, then categorized articles according to themes that emerged regarding epidemiology, effect on quality of life, disease progression, prognosis, pathophysiology, diagnosis, and treatment of parosmia.
resultsWe identified 123 unique references meeting eligibility and performed title and abstract review with 2 independent reviewers, with 74 articles undergoing full-text review. An inductive approach to thematic development provided 7 central themes regarding qualitative olfactory dysfunction following COVID-19.
conclusionsWhile other respiratory viruses are known to cause qualitative olfactory disturbances, the incidence of parosmia following COVID-19 is notable, and correlates negatively with age. The presence of parosmia predicts persistent quantitative olfactory dysfunction. Onset can occur months after infection, and symptoms may persist for well over 7 months. Affected patients report increased anxiety and decreased quality of life. Structured olfactory training with essential oils is the preferred treatment, where parosmia predicts recovery of aspects of quantitative smell loss when undergoing training. There is limited evidence that nasal corticosteroids may accelerate recovery of olfactory function. Patients should be prepared for the possibility that symptoms may persist for years, and providers should guide them to resources for coping with their psychosocial burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.