Evidence map›Paper›PMID 35957547›Full record

ArticleClinical and molecular hepatology2023

Hepatocellular carcinoma incidence is decreasing in Korea but increasing in the very elderly.

Young Eun Chon, Seong Yong Park, Han Pyo Hong, Donghee Son, Jonghyun Lee, Eileen Yoon, Soon Sun Kim, Sang Bong Ahn, Soung Won Jeong, Dae Won Jun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and molecular hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Young Eun ChonDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Seong Yong ParkBig Data Steering Department, National Health Insurance Service, Wonju, Korea.
Han Pyo HongBig Data Center, Department of Statistics, Yonsei University Wonju College of Medicine, Wonju, Korea.
Donghee SonBiostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, Korea.
Jonghyun LeeDepartment of Medical and Digital Engineering, Hanyang University College of Engineering, Seoul, Korea.
Eileen YoonDepartment of Internal Medicine, School of Medicine, Hanyang University, Seoul, Korea.
Soon Sun KimDepartment of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
Sang Bong AhnDepartment of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.
Soung Won JeongDepartment of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
Dae Won JunDepartment of Internal Medicine, School of Medicine, Hanyang University, Seoul, Korea.
Hanyang University · KRYonsei University · KRAjou University · KRBiostatistical Consulting (United States) · USCHA University Bundang Medical Center · KREulji University · KRSoonchunhyang University Hospital Seoul · KR

Funding

Korean Association for the study of the Liver 2019-05Soonchunhyang University
6 · The paper itself

Abstract

BACKGROUND/

aimsA comprehensive analysis of trends in the incidence of hepatocellular carcinoma (HCC) is important for planning public health initiatives. We aimed to analyze the trends in HCC incidence in South Korea over 10 years and to predict the incidence for the year 2028.

methodsData from patients with newly diagnosed HCC between 2008 and 2018 were obtained from Korean National Health Insurance Service database. Age-standardized incidence rates (ASRs) were calculated to compare HCC incidence. A poisson regression model was used to predict the future incidence of HCC.

resultsThe average crude incidence rate (CR) was 22.4 per 100,000 person-years, and the average ASR was 17.6 per 100,000 person-years between 2008 and 2018. The CR (from 23.9 to 21.2 per 100,000 person-years) and ASR (from 21.9 to 14.3 per 100,000 person-years) of HCC incidence decreased during the past ten years in all age groups, except in the elderly. The ASR of patients aged ≥80 years increased significantly (from 70.0 to 160.2/100,000 person-years; average annual percent change, +9.00%; P<0.001). The estimated CR (17.9 per 100,000 person-years) and ASR (9.7 per 100,000 person-years) of HCC incidence in 2028 was declined, but the number of HCC patients aged ≥80 years in 2028 will be quadruple greater than the number of HCC patients in 2008 (from 521 to 2,055), comprising 21.3% of all HCC patients in 2028.

conclusionThe ASRs of HCC in Korea have gradually declined over the past 10 years, but the number, CR, and ASR are increasing in patients aged ≥80 years.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAgedHumansIncidenceRegistriesRepublic of KoreaAge-standardized incidence rateHepatocellular carcinomaIncidenceKoreaPrediction

Identifiers

PMID35957547
PMCPMC9845660
OpenAlexW4291149557

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.