Evidence map›Paper›PMID 35957093›Full record

ArticleNanomaterials (Basel, Switzerland)2022

Biomolecular Corona Stability in Association with Plasma Cholesterol Level.

Duong N Trinh, Meda Radlinskaite, Jack Cheeseman, Gunter Kuhnle, Helen M I Osborn, Paula Meleady, Daniel I R Spencer, Marco P Monopoli

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Duong N TrinhDepartment of Chemistry, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.
Meda RadlinskaiteDepartment of Chemistry, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.
Jack CheesemanLudger Ltd., Culham Science Centre, Abingdon OX14 3EB, UK.ORCID 0000-0003-1112-217X
Gunter KuhnleDepartment of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6AH, UK.
Helen M I OsbornSchool of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, UK.
Paula MeleadySchool of Biotechnology, Dublin City University, D09 W6Y4 Dublin, Ireland.
Daniel I R SpencerLudger Ltd., Culham Science Centre, Abingdon OX14 3EB, UK.
Marco P MonopoliDepartment of Chemistry, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.ORCID 0000-0002-2035-6894

Funding

Irish Research Council EPSPG/2019/511Medical Research Council MR/P015786/1Royal College of Surgeons in Ireland RCSI International Secondment Awards 2020 (20077A07)
6 · The paper itself

Abstract

Biomolecular corona is spontaneously formed on the surface of nanoparticles (NPs) when they are in contact with biological fluids. It plays an important role in the colloidal stability of NPs, which is of importance for most of their medical applications and toxicity assessment. While typical studies use either blood plasma or serum from a pooled biobank, it is unclear whether differences in the media, such as cholesterol level or protein concentration, might affect the NP colloidal stability and corona composition. In this study, the silica corona was prepared at particularly low plasma concentrations (3%,

Indexed as

colloidal stabilitylipoproteinsprotein coronasilica nanoparticles

Identifiers

PMID35957093
PMCPMC9370777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.