Intramolecular Phosphine-Promoted Knoevenagel Based Redox-Reaction.

Niklas Feuge, Jan C Namyslo, Dieter E Kaufmann, René Wilhelm

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 54% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Niklas FeugeInstitute of Organic Chemistry, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany.ORCID 0000-0003-3523-0837

Jan C NamysloInstitute of Organic Chemistry, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany.

Dieter E KaufmannInstitute of Organic Chemistry, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany.ORCID 0000-0002-9790-828X

René WilhelmInstitute of Organic Chemistry, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany.ORCID 0000-0003-3856-2757

Clausthal University of Technology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A Knoevenagel based redox-reaction promoted by intramolecular phosphine sources is presented for the first time. The influence of different diketones, aldehydes, bases and acids was investigated. The effects of different substituents were evaluated based on their electronical influence on the diketone structure. With the obtained results a mechanism is proposed, giving information about transition states formed during the reaction, which can lead to different products. This type of an internal redox transformation with a phosphine oxide moiety remaining in the molecule after the redox reaction represents a new type of reaction.

Indexed as

PhosphinesCatalysisKetonesOxidation-ReductionStereoisomerismKetonesphosphinePhosphinesdiketonesKnoevenagel reactionmechanismphosphinesredox-reaction

Identifiers

PMID35956825

DOI10.3390/molecules27154875

PMCPMC9370043

OpenAlexW4289348127

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.