Evidence map›Paper›PMID 35956821›Full record

ReviewMolecules (Basel, Switzerland)2022

Natural Dietary Compounds in the Treatment of Arsenic Toxicity.

Geir Bjørklund, Md Shiblur Rahaman, Mariia Shanaida, Roman Lysiuk, Petro Oliynyk, Larysa Lenchyk, Salvatore Chirumbolo, Christos T Chasapis, Massimiliano Peana

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Article
  7. Article
  8. Metabolic Derangement by Arsenic: a Review of the Mechanisms.Biological trace element research · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. A review of mechanisms underlying the protective effects of natural compounds against arsenic-induced neurotoxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 5 countries.

Geir BjørklundCouncil for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway.ORCID 0000-0003-2632-3935
Md Shiblur RahamanDepartment of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke 329-0498, Japan.ORCID 0000-0002-9920-4809
Mariia ShanaidaDepartment of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.ORCID 0000-0003-1070-6739
Roman LysiukDepartment of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine.ORCID 0000-0003-0961-2970
Petro OliynykDepartment of Disaster Medicine and Military Medicine, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine.
Larysa LenchykDepartment of Chemistry of Natural Compounds, National University of Pharmacy, 61002 Kharkiv, Ukraine.
Salvatore ChirumboloDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-1789-8307
Christos T ChasapisNMR Facility, Instrumental Analysis Laboratory, School of Natural Sciences, University of Patras, 265 04 Patras, Greece.ORCID 0000-0002-8728-6245
Massimiliano PeanaDepartment of Chemical, Physics, Mathematics and Natural Sciences, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.ORCID 0000-0002-3306-0419
Danylo Halytsky Lviv National Medical University · UAI.Horbachevsky Ternopil National Medical University · UAJichi Medical University · JPNational University of Pharmacy · UAThe Research Council of Norway · NOUniversity of Patras · GRUniversity of Sassari · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin lesions and cancer being the most typical outcomes. Treating As-induced diseases continues to be challenging as there is no specific, safe, and efficacious therapeutic management. Therapeutic and preventive measures available to combat As toxicity refer to chelation therapy, antioxidant therapy, and the intake of natural dietary compounds. Although chelation therapy is the most commonly used method for detoxifying As, it has several side effects resulting in various toxicities such as hepatotoxicity, neurotoxicity, and other adverse consequences. Drugs of plant origin and natural dietary compounds show efficient and progressive relief from As-mediated toxicity without any particular side effects. These natural compounds have also been found to aid the elimination of As from the body and, therefore, can be more effective than conventional therapeutic agents in ameliorating As toxicity. This review provides an overview of the recently updated knowledge on treating As poisoning through natural dietary compounds. This updated information may serve as a basis for defining novel prophylactic and therapeutic formulations.

Indexed as

ArsenicArsenicalsArsenic PoisoningAntioxidantsHumansPlant ExtractsAntioxidantsArsenicArsenicalsPlant Extractsarsenicmedicinal plantsnatural compoundstoxicitytrace elementsvitamins

Identifiers

PMID35956821
PMCPMC9370003
OpenAlexW4289348337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.