Evidence map›Paper›PMID 35956766›Full record

ReviewMolecules (Basel, Switzerland)2022

Plants as a Source of Anticancer Agents: From Bench to Bedside.

Wamidh H Talib, Safa Daoud, Asma Ismail Mahmod, Reem Ali Hamed, Dima Awajan, Sara Feras Abuarab, Lena Hisham Odeh, Samar Khater, Lina T Al Kury

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Potential Anticancer Effect ofInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Mistletoe in Cancer Cell Biology: Recent Advances.Current issues in molecular biology · 2025
    Review
  7. Extract ofFood science & nutrition · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Allicin and Cancer Hallmarks.Molecules (Basel, Switzerland) · 2024
    Review
  18. Assessment of the anti-cancer potential ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Wamidh H TalibDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan.ORCID 0000-0003-1942-8982
Safa DaoudDepartment Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan.ORCID 0000-0003-1958-6534
Asma Ismail MahmodDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan.ORCID 0000-0002-4591-7408
Reem Ali HamedDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan.
Dima AwajanDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan.ORCID 0000-0002-1300-3353
Sara Feras AbuarabDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan.
Lena Hisham OdehDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan.
Samar KhaterDepartment of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan.
Lina T Al KuryDepartment of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi 144534, United Arab Emirates.ORCID 0000-0002-8338-7655
Applied Science Private University · JOZayed University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in cancer. In this review, we discussed the anticancer activities of ten natural products extracted from plants. The majority of these products inhibit cancer by targeting multiple cancer hallmarks, and many of these chemicals have reached clinical applications. Studies discussed in this review provide a solid ground for researchers and physicians to design more effective combination anticancer therapies using plant-derived natural products.

Indexed as

Antineoplastic AgentsBiological ProductsNeoplasmsCell Transformation, NeoplasticHumansPlant ExtractsAntineoplastic AgentsBiological ProductsPlant Extractsalternative cancer therapiesanticancerapoptosis inductionplant-derived natural productsplants

Identifiers

PMID35956766
PMCPMC9369847
OpenAlexW4288450179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.