Evidence map›Paper›PMID 35956421›Full record

ReviewNutrients2022

Epigenome Modulation Induced by Ketogenic Diets.

Paola Ungaro, Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Giovanna Muscogiuri, Annamaria Colao, Paolo Emidio Macchia

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  14. The Ketogenic Diet in Colorectal Cancer: A Means to an End.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Paola UngaroIstituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS) "Gaetano Salvatore", Consiglio Nazionale delle Ricerche, 80131 Naples, Italy.
Immacolata Cristina NettoreDipartimento di Medicina Clinica e Chirurgia, Scuola di Medicina, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
Fabiana FranchiniDipartimento di Medicina Clinica e Chirurgia, Scuola di Medicina, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
Giuseppe PalatucciDipartimento di Medicina Clinica e Chirurgia, Scuola di Medicina, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
Giovanna MuscogiuriUNESCO Chair on Health Education and Sustainable Development, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
Annamaria ColaoUNESCO Chair on Health Education and Sustainable Development, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
Paolo Emidio MacchiaUNESCO Chair on Health Education and Sustainable Development, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.ORCID 0000-0001-6503-6942
University of Naples Federico II · ITInstitute for Experimental Endocrinology and Oncology · IT

Funding

Ministero dll'Istruzione, università e Ricerca ARS01_00769
6 · The paper itself

Abstract

Ketogenic diets (KD) are dietary strategies low in carbohydrates, normal in protein, and high, normal, or reduced in fat with or without (Very Low-Calories Ketogenic Diet, VLCKD) a reduced caloric intake. KDs have been shown to be useful in the treatment of obesity, metabolic diseases and related disorders, neurological diseases, and various pathological conditions such as cancer, nonalcoholic liver disease, and chronic pain. Several studies have investigated the intracellular metabolic pathways that contribute to the beneficial effects of these diets. Although epigenetic changes are among the most important determinants of an organism's ability to adapt to environmental changes, data on the epigenetic changes associated with these dietary pathways are still limited. This review provides an overview of the major epigenetic changes associated with KDs.

Indexed as

Diet, KetogenicNervous System DiseasesDietary CarbohydratesEpigenomeHumansObesityDietary CarbohydratesDNA methylationhistone modificationsketogenic dietmiRNAsVery Low-Calories Ketogenic Diet

Identifiers

PMID35956421
PMCPMC9370515
OpenAlexW4292452300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.