ArticleNutrients2022
Trajectories of Lipid Profile and Risk of Carotid Atherosclerosis Progression: A Longitudinal Cohort Study.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Additional role of low-density lipoprotein cholesterol on the risk of osteoporosis in men with or without coronary heart disease: a real-world longitudinal study.Journal of geriatric cardiology : JGC · 2025Article
- Longitudinal TyG-BMI trajectories predict carotid atherosclerosis progression in a Chinese retrospective cohort.Frontiers in cardiovascular medicine · 2025Article
- Association between systemic inflammation response index trajectories and carotid atherosclerosis progression.Frontiers in endocrinology · 2025Article
- Estimated glucose disposal rate and non-HDL-c/HDL-c ratio with the progression of carotid atherosclerosis: a long-term cohort study.Frontiers in medicine · 2025Article
- Development and validation of a carotid plaque risk prediction model for coal miners.Frontiers in cardiovascular medicine · 2025Article
- The Impact of Triglyceride-Glucose Index Trajectories on Incidence and Recurrent Cardiovascular Events: Evidence from a Retrospective Cohort Study.Vascular health and risk management · 2025Article
- Chinese Medicine Formula HJ11 Alleviates Atherosclerosis by Inactivating the TLR4/MyD88/IκB-α Pathway and Modulating the Heart-Gut Axis Response.Journal of inflammation research · 2025Article
- No role of the third-trimester inflammatory factors in the association of gestational diabetes mellitus with postpartum cardiometabolic indicators.BMC pregnancy and childbirth · 2024Article
- Remnant cholesterol trajectory and subclinical arteriosclerosis: a 10-year longitudinal study of Chinese adults.Scientific reports · 2024Article
- Correlation between gestational diabetes mellitus and postpartum cardiovascular metabolic indicators and inflammatory factors: a cohort study of Chinese population.Frontiers in endocrinology · 2024Article
- Article
- Association between triglyceride-glucose index trajectories and carotid atherosclerosis progression.Cardiovascular diabetology · 2023Article
- Higher Leukocyte Count Is Associated with Lower Presence of Carotid Lipid-Rich Necrotic Core: A Sub-Study in the Plaque at RISK (PARISK) Study.Journal of clinical medicine · 2023Article
- Dysregulations of metabolites and gut microbes and their associations in rats with noise induced hearing loss.Frontiers in microbiology · 2023Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly assessment of carotid atherosclerotic plaque characteristics is essential for atherosclerotic cardiovascular disease (ASCVD) risk stratification and prediction. We aimed to identify different trajectories of lipid profiles and investigate the association of lipid trajectories with carotid atherosclerosis (CAS) progression in a large, longitudinal cohort of the Chinese population.
methods10,412 participants aged ≥18 years with ≥2 times general health checkups were included in this longitudinally prospective cohort study at Peking University Third Hospital. We used latent class trajectory models to identify trajectories of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) over follow-up time (757 days, IQR: 388-844 days).
resultsParticipants with carotid plaque were more likely to be older, male, have higher body mass index, have a higher prevalence of hypertension and diabetes, and have a higher level of blood pressure, TG, TC, and LDL-C, compared with carotid intima-media thickness (cIMT) and normal group. Subjects were trichotomized according to different trajectory patterns into stable, moderate-stable, and elevated-increasing classes. TC ≥ 5.18 mmol/L and moderate-stable class (hazard ratio (HR): 1.416, 95% confidence interval (CI): 1.285-1.559,
conclusionsBorderline elevated baseline lipid (TC, TG, and LDL-C) with stable and elevated-increasing trajectories were associated with CAS progression. Long-term strategies for low-level lipid are beneficial for ASCVD management.
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