SynthesisNutrients2022
Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 134000 Individuals in 29 Randomized Clinical Trials and 157000 Individuals in 30 Prospective Cohort Studies: An Updated Systematic Review and Meta-analysis.Journal of research in health sciences · 2023Pooled it
- Pooled it
- Pooled it
- Article
- [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Vitamin D and Health Outcomes: State-of-the-Art Review of Triangulated Evidence and Ongoing Controversies.Current nutrition reports · 2026Review
- The vitamin D-cardiovascular nexus unraveling mechanistic promise and trial reality.Nutrition & metabolism · 2026Review
- Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Successful large caloric deficit with high protein modification diet and intensive aerobic and resistance training with progressive overload in adult patient with significant coronary artery disease: a case report.Frontiers in cardiovascular medicine · 2026Article
- Identification of Priority Nutrients in the US: Targeting Malnutrition to Address Diet-Related Disease Across the Lifespan.Nutrients · 2025Article
- The role of Vitamin D supplementation in cardiovascular health: A reappraisal.Global cardiology science & practice · 2025Article
- Review
- Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives.Frontiers in molecular biosciences · 2025Review
- The association of vitamin deficiency with depression risk in late-life depression: a review.Frontiers in nutrition · 2025Review
- Joint association of vitamin D deficiency and sleep disorders with cardiovascular mortality: a prospective cohort study.Frontiers in nutrition · 2025Article
- Review
- Effect of vitamin D supplementation on cardiovascular outcomes: an updated meta-analysis of RCTs.Annals of medicine and surgery (2012) · 2024Review
- Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand.Frontiers in nutrition · 2024Article
- Associations between serum vitamin D status and the cardiometabolic profile of patients with obstructive sleep apnea.Hormones (Athens, Greece) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundlow vitamin D status has been associated with an increased incidence of cardiovascular events. However, whether vitamin D supplementation would reduce the incidence of cardiovascular events remains unclear. PURPOSE: To perform a systematic review and meta-analysis of the effect of vitamin D supplementation on the mortality and incidence of cardiovascular events. DATA SOURCES: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from their inception until 3 May 2022. STUDY SELECTION: Two authors searched for randomized clinical trials that reported vitamin D supplementation's effect on cardiovascular events outcomes. DATA EXTRACTION: Two authors conducted independent data extraction. DATA SYNTHESIS: We identified 41,809 reports; after exclusions, 18 trials with a total of 70,278 participants were eligible for analysis. Vitamin D supplementation was not associated with the mortality of cardiovascular events (RR 0.96, 95% CI 0.88-1.06, I LIMITATION: Cardiovascular events were the secondary outcome in most trials and thus, might be selectively reported.
conclusionIn this meta-analysis of randomized clinical trials, vitamin D supplementation was not associated with a lower risk of cardiovascular events than no supplementation. These findings do not support the routine use of vitamin D supplementation in general.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.