Evidence map›Paper›PMID 35956203›Full record

ArticleJournal of clinical medicine2022

Is Fetal Hydrops in Turner Syndrome a Risk Factor for the Development of Maternal Mirror Syndrome?

Ivonne Alexandra Bedei, Alexander Graf, Karl-Philipp Gloning, Matthias Meyer-Wittkopf, Daria Willner, Martin Krapp, Sabine Hentze, Alexander Scharf, Jan Degenhardt, Kai-Sven Heling and 17 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 12 institutions in 2 countries.

Ivonne Alexandra BedeiDepartment of Prenatal Diagnosis and Fetal Therapy, Justus-Liebig University, 35392 Giessen, Germany.ORCID 0000-0002-7688-5357
Alexander GrafDepartment of Prenatal Diagnosis and Fetal Therapy, Justus-Liebig University, 35392 Giessen, Germany.
Karl-Philipp GloningPrenatal Medicine and Genetics München, 80639 Munich, Germany.
Matthias Meyer-WittkopfCenter for Prenatal Diagnosis, Mathias-Spital Rheine, 48431 Rheine, Germany.
Daria WillnerCenter for Prenatal Medicine and Human Genetics, 20357 Hamburg, Germany.
Martin KrappCenter for Prenatal Medicine on Elbe, 20457 Hamburg, Germany.
Sabine HentzeCenter for Human Genetics, Cytogenetic Laboratory Heidelberg, 69120 Heidelberg, Germany.
Alexander ScharfCenter for Prenatal Medicine, 55116 Mainz, Germany.ORCID 0000-0002-4429-7710
Jan DegenhardtPraenatal Plus, Center for Prenatal Medicine and Genetics, 50672 Cologne, Germany.
Kai-Sven HelingCenter of Prenatal Diagnosis and Human Genetics, 10117 Berlin, Germany.
Peter KozlowskiPraenatal.de, Prenatal Medicine and Genetics Düsseldorf, 40210 Düsseldorf, Germany.
Kathrin TrautmannCenter for Prenatal Medicine "am Salzhaus", 60311 Frankfurt, Germany.
Kai JahnsDepartment of Internal Medicine, Johannes Gutenberg University, 55131 Mainz, Germany.
Anne GeipelObstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany.
Ismail TekesinPrenatal Medicine Stuttgart, 70173 Stuttgart, Germany.
Michael ElsässerDepartment of Gynecology and Obstetrics, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Lucas WilhelmWestend Ultrasound, Center for Prenatal Diagnosis and Fetal Echocardiography, 60325 Frankfurt, Germany.
Ingo GottschalkDivision of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Cologne, 50931 Cologne, Germany.
Jan-Erik BaumüllerGynaecologikum, Frankfurt, 60389 Frankfurt, Germany.
Cahit BirdirDepartment of Obstetrics and Gynecology, University Hospital Carl Gustav Carus Dresden, 01307 Dresden, Germany.
Felix ZöllnerDepartment of Prenatal Diagnosis and Fetal Therapy, Justus-Liebig University, 35392 Giessen, Germany.
Aline WolterDepartment of Prenatal Diagnosis and Fetal Therapy, Justus-Liebig University, 35392 Giessen, Germany.
Johanna SchenkDepartment of Prenatal Diagnosis and Fetal Therapy, Justus-Liebig University, 35392 Giessen, Germany.
Tascha GehrkeDepartment of Prenatal Diagnosis and Fetal Therapy, Justus-Liebig University, 35392 Giessen, Germany.
Corinna KeilDepartment of Prenatal Medicine and Fetal Therapy, Philipps University, 35041 Marburg, Germany.ORCID 0000-0002-1455-1319
Jimmy EspinosaBaylor College of Medicine Department of Obstetrics and Gynecology, Division of Fetal Therapy and Surgery and Texas Children's Hospital Fetal Center, Houston, TX 77030, USA.
Roland Axt-FliednerDepartment of Prenatal Diagnosis and Fetal Therapy, Justus-Liebig University, 35392 Giessen, Germany.
Justus-Liebig-Universität Gießen · DEAmedes MVZ Hamburg · DEBaylor College of Medicine · USHeidelberg University · DEJohannes Gutenberg University Mainz · DEKlinikum Rheine · DEPhilipps University of Marburg · DEStuttgart Observatory · DEUniversity Hospital Bonn · DEUniversity Hospital Carl Gustav Carus · DEUniversity of Cologne · DEZentrum für Pränataldiagnostik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mirror syndrome is a rare and serious maternal condition associated with immune and non-immune fetal hydrops after 16 weeks of gestational age. Subjacent conditions associated with fetal hydrops may carry different risks for Mirror syndrome. Fetuses with Turner syndrome are frequently found to be hydropic on ultrasound. We designed a retrospective multicenter study to evaluate the risk for Mirror syndrome among pregnancies complicated with Turner syndrome and fetal hydrops. Data were extracted from a questionnaire sent to specialists in maternal fetal medicine in Germany. Out of 758 cases, 138 fulfilled our inclusion criteria and were included in the analysis. Of the included 138, 66 presented with persisting hydrops at or after 16 weeks. The frequency of placental hydrops/placentomegaly was rather low (8.1%). Of note, no Mirror syndrome was observed in our study cohort. We propose that the risk of this pregnancy complication varies according to the subjacent cause of fetal hydrops. In Turner syndrome, the risk for Mirror syndrome is lower than that reported in the literature. Our observations are relevant for clinical management and parental counseling.

Indexed as

fetal hydropsMirror syndromemonosomy Xplacental hydropsplacentomegalyTurner syndrome

Identifiers

PMID35956203
PMCPMC9369874
OpenAlexW4290517633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.