Evidence map›Paper›PMID 35956194›Full record

ArticleJournal of clinical medicine2022

MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate.

Qi Zhang, Jinran Lin, Zhenghua Zhang, Ling Han, Qiong Huang, Jie Zhu, Bing Wang, Xu Fang, Zhizhong Zheng, Nikhil Yawalkar and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Qi ZhangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-4249-6409
Jinran LinDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhenghua ZhangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0001-9335-7022
Ling HanDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Qiong HuangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Jie ZhuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Bing WangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xu FangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhizhong ZhengDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Nikhil YawalkarDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-0024-338X
Jun LiangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Kexiang YanDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Fudan University · CNUniversity of Bern · CH

Funding

National Natural Science Foundation of China 81773322, 82173420Shanghai Key clinical specialty in 2019 3030247001Shanghai Municipal Key Clinical Specialty No-shslczdzk01002the Clinical Research Plan of SHDC SHDC2020CR6022, SHDC2020CR1014Bthe KeyProject in Basic Research Advocated by Shanghai Science and Technology Commission 13JC1402300
6 · The paper itself

Abstract

backgroundHyperhomocysteinemia has been reported in psoriasis. We investigated the effect of methylenetetrahydrofolate reductase (MTHFR), polymorphism and folic acid supplementation on serum homocysteine levels in psoriasis.

methodsSerum homocysteine levels were detected at baseline and at week 12 in 201 patients who were genotyped with MTHFR rs1801133 without and 93 psoriatic patients with folate supplement.

resultsTT genotype carriers of MTHFR rs1801133 had significantly higher serum homocysteine levels at baseline and at week 12, a better PASI 75 response rate at week 8, and a higher PASI 90 response rate at week 12 than the CT and CC genotype carriers. Multiple regression analysis demonstrated that serum homocysteine concentration at baseline was significantly associated with sex, weight, PASI score at baseline, and the rs1801133 genotype. The significant upregulation of serum homocysteine levels after treatment with methotrexate (MTX) was only observed in male CT and CC genotype carriers and female CC genotype carriers. In contrast, folic acid supplementation significantly decreased serum homocysteine levels after MTX treatment but only in male psoriatic patients.

conclusionsThe effect of MTX on serum homocysteine levels was associated with the polymorphism of MTHFR rs1801133 and sex. Folic acid supplementation only decreased serum homocysteine levels in male psoriatic patients.

Indexed as

homocysteinemethotrexatemethylenetetrahydrofolate reductasepsoriasisrs1801133

Identifiers

PMID35956194
PMCPMC9369514
OpenAlexW4290502428

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.