ArticleJournal of clinical medicine2022
High Tg/HDL-Cholesterol Ratio Highlights a Higher Risk of Metabolic Syndrome in Children and Adolescents with Severe Obesity.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Ratio That Reveals Risk: Defining TG:HDL-C Ratio Cutoff for Insulin Resistance in Adolescents with Obesity.Children (Basel, Switzerland) · 2026Article
- Differential Expression of microRNAs in Obese Mexican Children: Links to Insulin Resistance and Dyslipidemia.International journal of molecular sciences · 2026Observational
- Comparative diagnostic accuracy of the triglyceride/HDL-c ratio and lipid accumulation product index for the early detection of metabolic syndrome among adults with obesity in Indonesia: findings from the 2023 Health Survey.Archives of endocrinology and metabolism · 2026Article
- Aerobic fitness, lipid ratio, visceral adiposity index and risk of hypertension in adolescents: An observational study.World journal of clinical pediatrics · 2025Article
- Cross-sectional association of fitness, fatness, and dyslipidemia with metabolic syndrome in youth.World journal of clinical pediatrics · 2025Article
- Assessing Metabolic Syndrome Risk in Children and Adolescents with Prader-Willi Syndrome: A Comparison of Index Performance.Journal of clinical medicine · 2025Article
- Predictive Accuracy of Biochemical and Anthropometric Indices for Metabolic Syndrome in Children with Obesity: A Comparative Study.Life (Basel, Switzerland) · 2025Article
- Utility of the TG/HDL-C Ratio in Estimating Pediatric Cardiometabolic Risk in a Community Hospital.Children (Basel, Switzerland) · 2024Article
- Impact of Weight Status on Hemodynamic Parameters and Aerobic Fitness in School-Aged Children: A Study in a Rural School Community.International journal of environmental research and public health · 2024Article
- Associations of cardiometabolic index with diabetic statuses and insulin resistance: the mediating role of inflammation-related indicators.BMC public health · 2024Article
- Comparison of obesity indicators for predicting cardiovascular risk factors and multimorbidity among the Chinese population based on ROC analysis.Scientific reports · 2024Article
- Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study.Cardiovascular diabetology · 2024Article
- The Lipid Accumulation Product Index (LAP) and the Cardiometabolic Index (CMI) Are Useful for Predicting the Presence and Severity of Metabolic Syndrome in Adult Patients with Obesity.Journal of clinical medicine · 2024Article
- The neutrophil to lymphocyte ratio (NLR) positively correlates with the presence and severity of metabolic syndrome in obese adults, but not in obese children/adolescents.BMC endocrine disorders · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Few data are currently available on the reliability of the different anthropometric, instrumental and biochemical indexes in recognizing the presence of metabolic syndrome (MetS) in children and adolescents with severe obesity. Therefore, the objective of our study was to find out the simplest and most accurate predictive index of MetS in this population at-risk. In 1065 children and adolescents (563 f, 502 m), aged 14.6 ± 2.1 years (range 10-17), with severe obesity [BMI-SDS 3.50 ± 0.36 (range 3.00-5.17)], the following indexes were evaluated: BMI, BMI-SDS, Tri-Ponderal Mass Index, Waist-to-Height ratio, TG/HDL-Cholesterol ratio, Cardiometabolic Index (CMI), and Visceral Adiposity Index (VAI). For each subject, all the components of MetS, defined according to the IDF criteria, were determined. Overall, the presence of MetS was found in 324 patients (30.4%), 167 males (33.3%) and 157 females (27.9%). According to the ROC analysis, three indexes (VAI, CMI and TG/HDL-Cholesterol ratio), performed significantly better than the other ones in identifying MetS, with no difference among them. In conclusion, the TG/HDL ratio, which just needs the evaluation of two simple biochemical parameters, offers the same accuracy as other more sophisticated indexes in recognizing MetS in children and adolescents with severe obesity, thus making it the best predictor to be easily used.
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