ArticleJournal of clinical medicine2022
Prospective Association between Multimorbidity and Falls and Its Mediators: Findings from the Irish Longitudinal Study on Ageing.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Cardiovascular Disorders and Falls Among Older Adults: A Systematic Review and Meta-Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- Mechanistic Pathways Linking Type 2 Diabetes Mellitus, Hypertension, and Osteoarthritis to Falls in Older Adults: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Longitudinal association between chronic diseases and fall risk among middle-aged and older adults in China: the mediating role of activity limitations.Journal of global health · 2026Article
- The associations of multimorbidity with fall- and fracture-related hospitalisations: the Busselton Healthy Ageing Study.Archives of osteoporosis · 2025Article
- Risk of Diminished Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs) After an Older Adult Fall, Medicare Current Beneficiary Survey, 2015-2020.American journal of lifestyle medicine · 2025Article
- Multimorbidity, Muscle Strength, and Falls among Older Mexican Americans.Journal of the American Medical Directors Association · 2025Article
- Multimorbidity, medications, and their association with falls, physical activity, and cognitive functions in older adults: multicenter study in Sri Lanka.Scientific reports · 2025Article
- Article
- Relationship between Social Participation, Children's Support, and Social Frailty with Falls among Older Adults in Colombia.Annals of geriatric medicine and research · 2024Article
- Multimorbidity patterns and the risk of falls among older adults: a community-based study in China.BMC geriatrics · 2024Article
- Chronic pain in older adults with disabilities is associated with fall-related injuries: a prospective cohort study.European geriatric medicine · 2024Article
- Bidirectional association between falls and multimorbidity in middle-aged and elderly Chinese adults: a national longitudinal study.Scientific reports · 2024Article
- The role of ultrasonographically measured rectus femoris muscle on falls in community-dwelling older adults: a single-center study.European geriatric medicine · 2023Article
- Multimorbidity Patterns and Associations with Gait, Balance and Lower Extremity Muscle Function in the Elderly: A Cross-Sectional Study in Northwest China.International journal of general medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study including older adults from Ireland aimed to analyze the prospective association between multimorbidity and falls and to identify the mediators in this relationship. The present study used data from two consecutive waves of the Irish Longitudinal Study on Ageing (TILDA) survey. Multimorbidity was assessed at Wave 1 (2009-2011) and was defined as the presence of at least two chronic conditions. Falls occurring at Wave 2 (2012-2013) were self-reported. Mediating variables considered were polypharmacy, cognitive impairment, sleep problems, pain, low handgrip strength, difficulty in activities of daily living (ADL), obesity, and underweight. Multivariable binary logistic regression and mediation analysis using the Karlson Holm Breen method were conducted. This study included 6900 adults aged ≥50 years (51.6% women; mean [SD] age 63.1 [8.9] years). Compared to no chronic conditions at baseline, there was a positive and significant association between multimorbidity and falls at follow-up, with ORs ranging from 1.32 (95% CI = 1.06-1.64) for 2 conditions to 1.92 (95% CI = 1.54-2.38) for ≥4 conditions. Pain (23.5%), polypharmacy (13.3%), and difficulty in ADL (10.7%) explained the largest proportion of the multimorbidity-fall relationship. Multimorbidity increased risk for incident falls in older adults from Ireland. Interventions should be implemented to reduce fall risk in people with multimorbidity, especially targeting the identified mediators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.