Evidence map›Paper›PMID 35956032›Full record

ArticleJournal of clinical medicine2022

Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study.

Lan Geng, Xinran Lin, Rang Liu, Jiahui Wu, Yongsheng Luo, Hongmei Sun, Zhenhui Hou, Qiuju Zhang, Chang Xu, Xiao Li and 3 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lan GengCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.
Xinran LinMedical College, Shantou University Medical College, Shantou 515063, China.
Rang LiuCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.
Jiahui WuDepartment of Gynecology, Shenzhen Maternity & Child Healthcare Hospital, Shenzhen 518000, China.
Yongsheng LuoQuality Control Department, The Second People's Hospital of Futian District, Shenzhen 518000, China.
Hongmei SunCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.
Zhenhui HouCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.
Qiuju ZhangCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.
Chang XuCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.
Xiao LiShenzhen Health Capacity Building and Continuing Education Center, Shenzhen 518000, China.
Canhui CaoCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.ORCID 0000-0002-7328-0264
Tianren WangCenter for Reproductive Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518000, China.
Xi XiaCenter for Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518000, China.

Funding

National Natural Science Foundation of China No.81971453Research Team of Female Reproductive Health and Fertility Preservation SZSM201612065Shenzhen Fundamental Research Program JCYJ20200109150429414Shenzhen Fundamental Research Program JCYJ20210324105808022
6 · The paper itself

Abstract

introductionWe explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture.

methodsThe data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18-22 h) after thawing were analyzed. Based on the growth rate after the overnight culture, the embryos were divided into three groups: no embryo reaching eight cells (Group I), either one of the two embryos reaching eight cells (Group II), and both two embryos reaching eight cells or more (Group III). A statistical analysis of the different clinical outcomes from the three groups was performed.

resultsBiochemical pregnancy rate (OR 3.22;

conclusionsThe capability of day-3 cleavage slow-growing embryos to reach eight cells, especially that of two embryos reaching eight cells by overnight culture, appear to result in a better pregnancy outcome.

Indexed as

cleavage ratefrozen embryo transferovernight cultureslow-growing embryo

Identifiers

PMID35956032
PMCPMC9369477

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.