Evidence map›Paper›PMID 35955953›Full record

ArticleInternational journal of molecular sciences2022

Hyaluronic Acid Alleviates Oxidative Stress and Apoptosis in Human Tenocytes via Caspase 3 and 7.

Marialucia Gallorini, Cristina Antonetti Lamorgese Passeri, Amelia Cataldi, Anna Concetta Berardi, Leonardo Osti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Review of Preclinical and Clinical Studies Supporting the Role of Polydeoxyribonucleotide in the Treatment of Tendon Disorders.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  9. Article
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  12. Article
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  15. Hyaluronic Acid as a Modern Approach in Anticancer Therapy-Review.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Marialucia GalloriniDepartment of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.ORCID 0000-0002-2283-4159
Cristina Antonetti Lamorgese PasseriLaboratory of Stem Cells, Department of Haematology, Transfusion Medicine and Biotechnologies, Santo Spirito Hospital, 65124 Pescara, Italy.
Amelia CataldiDepartment of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Anna Concetta BerardiLaboratory of Stem Cells, Department of Haematology, Transfusion Medicine and Biotechnologies, Santo Spirito Hospital, 65124 Pescara, Italy.ORCID 0000-0002-5078-6158
Leonardo OstiUnit of Arthroscopy and Sports Medicine, Hesperia Hospital, 41125 Modena, Italy.
Ospedale di Santo Spirito · ITUniversity of Chieti-Pescara · ITHesperia Hospital · IT

Funding

Programma Operativo Nazionale (PON) Ricerca e Innovazione 2014-2020, Fondo Sociale Euro-peo, Azione I. 2 "Attrazione e Mobilità Internazionale dei Ricercatori" (Dr. Marialucia Gallori-ni). PON 2014-2020
6 · The paper itself

Abstract

Rotator cuff tendinopathy (RCT) is the primary reason for shoulder surgery and its clinical management is still challenging. Hyaluronic acid (HA) has been shown to have anti-inflammatory effects in vitro and in vivo under RCT conditions, characterized by an exaggerated oxidative stress (OS). However, molecular mechanisms underlying HA-related effects are still partially disclosed. With these aims, a cell model of RCT was established by exposing primary human tenocytes to H

Indexed as

TendinopathyTenocytesAntioxidantsApoptosisCaspase 3Caspase 7Collagen Type IHumansHyaluronic AcidOxidative StressAntioxidantsCASP3 protein, humanCASP7 protein, humanCaspase 3Caspase 7Collagen Type IHyaluronic Acidapoptosisascorbic acidcaspasecollagenhyaluronic acidinflammationmolecular weightnitic oxideoxidative stresstendon

Identifiers

PMID35955953
PMCPMC9368776
OpenAlexW4293275358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.