Evidence map›Paper›PMID 35955916›Full record

ArticleInternational journal of molecular sciences2022

Downregulation of the Cd38-Cyclic ADP-Ribose Signaling in Cardiomyocytes by Intermittent Hypoxia via Pten Upregulation.

Shin Takasawa, Mai Makino, Tomoko Uchiyama, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Asako Itaya-Hironaka, Yoshinori Takeda, Keito Asai, Ryogo Shobatake, Hiroyo Ota

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The Impact of Intermittent Hypoxia on Metabolism and Cognition.International journal of molecular sciences · 2022
    Review
  6. Upregulation ofInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shin TakasawaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0002-4066-0199
Mai MakinoDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Tomoko UchiyamaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Akiyo YamauchiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0001-9417-4738
Sumiyo Sakuramoto-TsuchidaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Asako Itaya-HironakaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Yoshinori TakedaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0001-7738-5576
Keito AsaiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ryogo ShobatakeDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0002-4165-1200
Hiroyo OtaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nara Medical University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology, Japan 08102003Ministry of Education, Culture, Sports, Science and Technology, Japan 15K19425Ministry of Education, Culture, Sports, Science and Technology, Japan 21K16344
6 · The paper itself

Abstract

Sleep apnea syndrome (SAS) is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia, IH), and it is a risk factor for cardiovascular disease (CVD) and insulin resistance/type 2 diabetes. However, the mechanisms linking IH stress and CVD remain elusive. We exposed rat H9c2 and mouse P19.CL6 cardiomyocytes to experimental IH or normoxia for 24 h to analyze the mRNA expression of the components of Cd38-cyclic ADP-ribose (cADPR) signaling. We found that the mRNA levels of cluster of differentiation 38 (

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2ADP-ribosyl CyclaseADP-ribosyl Cyclase 1AnimalsCalcium SignalingCyclic ADP-RiboseDown-RegulationHypoxiaMembrane GlycoproteinsMiceMyocytes, CardiacPTEN PhosphohydrolaseRatsRNA, MessengerRyanodine Receptor Calcium Release ChannelADP-ribosyl CyclaseADP-ribosyl Cyclase 1Cd38 protein, ratCyclic ADP-RiboseMembrane GlycoproteinsPTEN PhosphohydrolasePten protein, ratRNA, MessengerRyanodine Receptor Calcium Release ChannelcardiomyocytesCd38Fkbp12.6intermittent hypoxiaPtenRyr2sleep apnea syndrome

Identifiers

PMID35955916
PMCPMC9368863
OpenAlexW4290493706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.