Evidence map›Paper›PMID 35955891›Full record

ArticleInternational journal of molecular sciences2022

PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer.

Shoshana Sedley, Jeetendra Kumar Nag, Tatyana Rudina, Rachel Bar-Shavit

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. PARInternational journal of molecular sciences · 2025
    Article
  3. New Target(s) for RNF43 Regulation: Implications for Therapeutic Strategies.International journal of molecular sciences · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shoshana SedleySharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.ORCID 0000-0003-3608-1255
Jeetendra Kumar NagSharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Tatyana RudinaSharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Rachel Bar-ShavitSharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.ORCID 0000-0003-1162-9974
Hadassah Medical Center · IL

Funding

Israel Science Foundation 1420
6 · The paper itself

Abstract

G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell maintenance is still lacking. In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation are poorly understood. Here, we find that protease-activated receptor 4 (PAR

Indexed as

beta CateninColonic NeoplasmsEnhancer of Zeste Homolog 2 ProteinHumansLysineNeoplastic Stem CellsSignal Transductionbeta CateninEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanLysinecolon cancerEZH2GPCRprotease-activated receptors (PARs)

Identifiers

PMID35955891
PMCPMC9368822
OpenAlexW4290516504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.