Evidence map›Paper›PMID 35955884›Full record

ArticleInternational journal of molecular sciences2022

The Effect of Isosaponarin Derived from Wasabi Leaves on Glutamate Release in Rat Synaptosomes and Its Underlying Mechanism.

Cheng-Wei Lu, Kun-Chieh Yeh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
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  4. International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cheng-Wei LuDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-2217-3231
Kun-Chieh YehSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Kuan-Ming ChiuDivision of Cardiovascular Surgery, Cardiovascular Center, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-7597-7655
Ming-Yi LeeDepartment of Medical Research, Far-Eastern Memorial Hospital, New Taipei 22060, Taiwan.ORCID 0000-0001-7742-9508
Tzu-Yu LinDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.
Su-Jane WangSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0002-4675-0259
Far Eastern Memorial Hospital · TWFu Jen Catholic University · TW

Funding

Ministry of Science and Technology, Taiwan ; MOST 110-2314-B-418 -008Ministry of Science and Technology, Taiwan MOST 110-2320-B-030-009Taoyuan Armed Forces General Hospital, Taiwan TYAFGH-A-111017
6 · The paper itself

Abstract

Excessive glutamate release is known to be involved in the pathogenesis of neurological diseases, and suppression of glutamate release from nerve terminals is considered to be a treatment strategy. In this study, we investigated whether isosaponarin, a flavone glycoside isolated from wasabi leaves, could affect glutamate release in rat cerebral cortex nerve terminals (synaptosomes). The release of glutamate was evoked by the K

Indexed as

Glutamic AcidSynaptosomesAnimalsCalciumCalcium Channel BlockersCerebral CortexMembrane PotentialsNerve EndingsRatsRats, Sprague-DawleyCalciumCalcium Channel BlockersGlutamic AcidisosaponarinMARCKSPKCSNAP-25vesicular glutamate releaseVGCC

Identifiers

PMID35955884
PMCPMC9368944
OpenAlexW4290599954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.