Evidence map›Paper›PMID 35955699›Full record

ArticleInternational journal of molecular sciences2022

MicroRNA-7a2 Contributes to Estrogen Synthesis and Is Modulated by FSH via the JNK Signaling Pathway in Ovarian Granulosa Cells.

Liuhui Li, Jinglin Zhang, Chenyang Lu, Bingjie Wang, Jiajia Guo, Haitong Zhang, Sheng Cui

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Liuhui LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jinglin ZhangInstitute of Reproduction and Metabolism, Yangzhou University, Yangzhou 225009, China.
Chenyang LuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Bingjie WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jiajia GuoCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Haitong ZhangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Sheng CuiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yangzhou University · CN

Funding

National Key Research and Development Program of China 2018YFC1003800National Natural Science Foundation of China 31772692Natural Science Foundation of Jiangsu Province BK20190879Postgraduate Research & Practice Innovation Program of Jiangsu Province (Yangzhou University) XKYCX18_104Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) no
6 · The paper itself

Abstract

MicroRNA-7a2 (miR-7a2) plays fundamental roles in the female reproductive axis, and estrogen is indispensable for maintaining ovary function. However, the interaction between miR-7a2 and ovarian function is unclear. The present study aimed to determine whether and how miR-7a2 functions in estrogen synthesis. Firstly, the results verified that miR-7a was highly expressed in ovarian granulosa cells. The knockout (KO) of miR-7a2 caused infertility and abnormal ovarian function in mice. Concomitantly, the

Indexed as

InfertilityMicroRNAsAnimalsEstrogensFemaleFollicle Stimulating HormoneGranulosa CellsMAP Kinase Signaling SystemMiceEstrogensFollicle Stimulating HormoneMicroRNAsCyp19a1estrogen synthesisGlg1JNKmicroRNA-7a2ovary

Identifiers

PMID35955699
PMCPMC9369042
OpenAlexW4289524112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.