Evidence map›Paper›PMID 35955688›Full record

ReviewInternational journal of molecular sciences2022

The Screening of Therapeutic Peptides for Anti-Inflammation through Phage Display Technology.

Kangran Zhang, Yezhong Tang, Qin Chen, Yang Liu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  3. Review
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  7. Review
  8. Genetically Engineered Microorganisms and Their Impact on Human Health.International journal of clinical practice · 2024
    Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kangran ZhangChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.ORCID 0000-0003-1148-7187
Yezhong TangChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Qin ChenChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Yang LiuChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.ORCID 0000-0003-1725-8721
Chinese Academy of Sciences · CN

Funding

National Key R&D Program of China 2018YFB1304702National Natural Science Foundation of China 31970423National Natural Science Foundation of China 32071242the Science and Technology Project in Sichuan Province 2022NSFSC0579
6 · The paper itself

Abstract

For the treatment of inflammatory illnesses such as rheumatoid arthritis and carditis, as well as cancer, several anti-inflammatory medications have been created over the years to lower the concentrations of inflammatory mediators in the body. Peptides are a class of medication with the advantages of weak immunogenicity and strong activity, and the phage display technique is an effective method for screening various therapeutic peptides, with a high affinity and selectivity, including anti-inflammation peptides. It enables the selection of high-affinity target-binding peptides from a complex pool of billions of peptides displayed on phages in a combinatorial library. In this review, we will discuss the regular process of using phage display technology to screen therapeutic peptides, and the peptides screened for anti-inflammation properties in recent years according to the target. We will describe how these peptides were screened and how they worked in vitro and in vivo. We will also discuss the current challenges and future outlook of using phage display to obtain anti-inflammatory therapeutic peptides.

Indexed as

BacteriophagesCell Surface Display TechniquesAnti-Inflammatory AgentsPeptide LibraryPeptidesProtein BindingTechnologyAnti-Inflammatory AgentsPeptide LibraryPeptidesanti-inflammatory peptidesinflammation pathwayinflammation targetphage displaytherapeutic peptide

Identifiers

PMID35955688
PMCPMC9368796
OpenAlexW4289524072

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.