Evidence map›Paper›PMID 35955616›Full record

ArticleInternational journal of molecular sciences2022

Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases.

Jerko Štambuk, Frano Vučković, Siniša Habazin, Maja Hanić, Mislav Novokmet, Susanna Nikolaus, Florian Tran, Stefan Schreiber, Andre Franke, Philip Rosenstiel and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  4. Endothelial cells sialylate IgG within the FcRn-mediated recycling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Jerko ŠtambukGenos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.
Frano VučkovićGenos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.
Siniša HabazinGenos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.ORCID 0000-0003-0615-3529
Maja HanićGenos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.ORCID 0000-0001-6152-2054
Mislav NovokmetGenos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.
Susanna NikolausDepartment of Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Florian TranDepartment of Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.ORCID 0000-0002-3735-9872
Stefan SchreiberDepartment of Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Andre FrankeDepartment of Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Philip RosenstielDepartment of Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Gordan LaucGenos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.
Konrad AdenDepartment of Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Marija PezerGenos Glycoscience Research Laboratory, 10000 Zagreb, Croatia.
Genos (Croatia) · HRChristian-Albrechts-Universität zu Kiel · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Zagreb · HR

Funding

European Union 733100
6 · The paper itself

Abstract

Immunosuppressants and biologicals are widely used therapeutics for various chronic inflammatory diseases (CID). To gain more detailed insight into their downstream effects, we examined their impact on serum immunoglobulin G (IgG) glycosylation. We analyzed IgG subclass-specific fragment crystallizable (Fc) N-glycosylation in patients suffering from various CID using the LC-MS approach. Firstly, we compared IgG Fc N-glycosylation between 128 CID patients and 204 healthy controls. Our results replicated previously observed CID-related decrease in IgG Fc galactosylation (adjusted

Indexed as

Immunoglobulin Fc FragmentsImmunoglobulin GChromatography, LiquidGlycosylationHumansMass SpectrometryImmunoglobulin Fc FragmentsImmunoglobulin Gautoimmune diseaseschronic inflammatory diseasesIgG glycosylationinflammatory bowel diseasepersonalized medicineresponse

Identifiers

PMID35955616
PMCPMC9368836
OpenAlexW4289175454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.