Evidence map›Paper›PMID 35955595›Full record

ArticleInternational journal of molecular sciences2022

Buffalo Milk Whey Activates Necroptosis and Apoptosis in a Xenograft Model of Colorectal Cancer.

Nunzio Antonio Cacciola, Angela Salzano, Nunzia D'Onofrio, Tommaso Venneri, Paola De Cicco, Francesco Vinale, Orsolina Petillo, Manuela Martano, Paola Maiolino, Gianluca Neglia and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Structural and morphological modulation of the myocardium byBiochemistry and biophysics reports · 2026
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  6. Review
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  9. Use of Cyanobacterium Spirulina (Foods (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Nunzio Antonio CacciolaDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.ORCID 0000-0002-0780-9844
Angela SalzanoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.ORCID 0000-0003-2199-7092
Nunzia D'OnofrioDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.ORCID 0000-0002-5300-9530
Tommaso VenneriDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-0195-2081
Paola De CiccoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.
Francesco VinaleDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.ORCID 0000-0002-5090-8127
Orsolina PetilloResearch Institute on Terrestrial Ecosystems (IRET), UOS Naples-Consiglio Nazionale delle Ricerche (CNR), Via Pietro Castellino 111, 80131 Naples, Italy.
Manuela MartanoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.ORCID 0000-0002-1577-4223
Paola MaiolinoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.
Gianluca NegliaDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.ORCID 0000-0002-0989-6072
Ciro CampanileInstitute of Genetics and Biophysics "Adriano Buzzati Traverso", Consiglio Nazionale delle Ricerche (CNR), 80131 Naples, Italy.
Lorella SeverinoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.
Carmine MerolaFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via Balzarini 1, 64100 Teramo, Italy.
Francesca BorrelliDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-2695-3294
Maria Luisa BalestrieriDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy.ORCID 0000-0001-6001-1789
Giuseppe CampanileDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.ORCID 0000-0002-3242-7274
University of Naples Federico II · ITNational Research Council · ITUniversity of Campania "Luigi Vanvitelli" · ITInstitute of Genetics and Biophysics · ITUniversity of Teramo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent pharmacological research on milk whey, a byproduct of the dairy industry, has identified several therapeutic properties that could be exploited in modern medicine. In the present study, we investigated the anticancer effects of whey from Mediterranean buffalo (

Indexed as

Colorectal NeoplasmsSirtuinsAnimalsApoptosisBuffaloesHeterograftsHumansMiceMilkNecroptosisPeroxisome Proliferator-Activated ReceptorsReceptor-Interacting Protein Serine-Threonine KinasesWheyPeroxisome Proliferator-Activated ReceptorsReceptor-Interacting Protein Serine-Threonine KinasesSIRT6 protein, humanSirt6 protein, mouseSirtuinsapoptosiscolorectal cancerdelactosed milk wheynecroptosisxenograft

Identifiers

PMID35955595
PMCPMC9368892
OpenAlexW4289175902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.