Evidence map›Paper›PMID 35955590›Full record

ArticleInternational journal of molecular sciences2022

Free Cholesterol Affects the Function and Localization of Human Na

Jessica Y Idowu, Bruno Hagenbuch

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jessica Y IdowuDepartment of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Bruno HagenbuchDepartment of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID 0000-0002-2938-8630
University of Kansas Medical Center · US

Funding

Pilot Grants ProgramP30GM118247 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2016 to 2020
$5.5M
Molecular Characterization of Hepatic Organic Anion Transporting PolypeptidesR01GM077336 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI HAGENBUCH, BRUNO · 2007 to 2019
$3.7M
NIGMS NIH HHS P30 GM118247NIGMS NIH HHS P30GM1182471NIGMS NIH HHS R01 GM077336NIGMS NIH HHS R01GM077336
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with obesity. They are accompanied by increased levels of free cholesterol in the liver. Most free cholesterol resides within the plasma membrane. We assessed the impact of adding or removing free cholesterol on the function and localization of two hepatocellular uptake transporters: the Na

Indexed as

Non-alcoholic Fatty Liver DiseaseSymportersBile Acids and SaltsCholesterolHumansLiverOctamer Transcription Factor-1Organic Anion Transporters, Sodium-DependentOrganic Cation Transporter 1PeptidesTaurocholic AcidBile Acids and SaltsCholesterolOctamer Transcription Factor-1Organic Anion Transporters, Sodium-DependentOrganic Cation Transporter 1PeptidesPOU2F1 protein, humanSymportersTaurocholic Acidcholesterolcholesterol-methyl-β-cyclodextrinlipid raftmethyl-β-cyclodextrinNTCPOCT1transporter

Identifiers

PMID35955590
PMCPMC9368832
OpenAlexW4289175828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.