Evidence map›Paper›PMID 35955574›Full record

ArticleInternational journal of molecular sciences2022

Cardiotoxicity of Zebrafish Induced by 6-Benzylaminopurine Exposure and Its Mechanism.

Mengying Yang, Jialu Luan, Yixin Xu, Chengtian Zhao, Mingzhu Sun, Xizeng Feng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mengying YangState Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, College of Life Science, Ministry of Education, Nankai University, Tianjin 300071, China.
Jialu LuanState Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, College of Life Science, Ministry of Education, Nankai University, Tianjin 300071, China.
Yixin XuState Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, College of Life Science, Ministry of Education, Nankai University, Tianjin 300071, China.
Chengtian ZhaoState Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, College of Life Science, Ministry of Education, Nankai University, Tianjin 300071, China.
Mingzhu SunThe Institute of Robotics and Automatic Information Systems, Nankai University, Tianjin 300071, China.
Xizeng FengState Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, College of Life Science, Ministry of Education, Nankai University, Tianjin 300071, China.
Nankai University · CNState Key Laboratory of Medicinal Chemical Biology

Funding

Special Fund for Basic Research on Scientific Instruments of the Chinese National Natural Science Foundation 62027812the National Key R&D Program of China 2019YFB1309704
6 · The paper itself

Abstract

6-BA is a common plant growth regulator, but its safety has not been conclusive. The heart is one of the most important organs of living organisms, and the cardiogenesis process of zebrafish is similar to that of humans. Therefore, based on wild-type and transgenic zebrafish, we explored the development of zebrafish heart under 6-BA exposure and its mechanism. We found that 6-BA affected larval cardiogenesis, inducing defective expression of key genes for cardiac development (

Indexed as

CardiotoxicityZebrafishAnimalsBenzyl CompoundsEmbryo, NonmammalianHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPurinesZebrafish ProteinsbenzylaminopurineBenzyl CompoundsPurinesZebrafish Proteins6-benzylaminopurinecardiotoxicityHPA axis activityinflammationzebrafish

Identifiers

PMID35955574
PMCPMC9369308
OpenAlexW4289134964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.