Evidence map›Paper›PMID 35955551›Full record

ArticleInternational journal of molecular sciences2022

Large-Scale Identification of Multiple Classes of Host Defense Peptide-Inducing Compounds for Antimicrobial Therapy.

Wentao Lyu, Dehui Mi, Paige N Vinson, Yingping Xiao, Guolong Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Regulation of Host Defense Peptide Synthesis by Polyphenols.Antibiotics (Basel, Switzerland) · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Wentao LyuState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.ORCID 0000-0001-8496-4525
Dehui MiVanderbilt High-Throughput Screening Facility, Vanderbilt Institute of Chemical Biology, Nashville, TN 37232, USA.
Paige N VinsonVanderbilt High-Throughput Screening Facility, Vanderbilt Institute of Chemical Biology, Nashville, TN 37232, USA.ORCID 0000-0003-0285-3376
Yingping XiaoState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Guolong ZhangDepartment of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0003-4781-5816
Oklahoma State University · USZheJiang Academy of Agricultural Sciences · CN

Funding

Oklahoma Center for the Advancement of Science and Technology AR19-027United States Department of Agriculture 2018-68003-27462 and 2020-67016-31619
6 · The paper itself

Abstract

The rapid emergence of antibiotic resistance demands new antimicrobial strategies that are less likely to develop resistance. Augmenting the synthesis of endogenous host defense peptides (HDPs) has been proven to be an effective host-directed therapeutic approach. This study aimed to identify small-molecule compounds with a strong ability to induce endogenous HDP synthesis for further development as novel antimicrobial agents. By employing a stable HDP promoter-driven luciferase reporter cell line known as HTC/

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesAnimalsAnti-Bacterial AgentsChickensMacrophagesPhosphatidylinositol 3-KinasesAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesPhosphatidylinositol 3-Kinasesantimicrobial resistancehigh-throughput screeninghost defense peptide inducershost defense peptidesmocetinostat

Identifiers

PMID35955551
PMCPMC9368921
OpenAlexW4289134375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.