Evidence map›Paper›PMID 35955536›Full record

ArticleInternational journal of molecular sciences2022

New Imaging Modality of COVID-19 Pneumonia Developed on the Basis of Alzheimer's Disease Research.

Przemysław Koźmiński, Dorota Niedziałek, Grzegorz Wieczorek, Paweł K Halik, Kamila Czarnecka, Aleksandra Rogut, Łukasz Cheda, Zbigniew Rogulski, Paweł Szymański, Ewa Gniazdowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Przemysław KoźmińskiCentre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland.ORCID 0000-0003-0471-6949
Dorota NiedziałekInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.ORCID 0000-0003-3129-4577
Grzegorz WieczorekInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Paweł K HalikCentre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland.ORCID 0000-0003-0657-3793
Kamila CzarneckaDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Medical University, 1 Muszynskiego St., 90-151 Lodz, Poland.
Aleksandra RogutDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Medical University, 1 Muszynskiego St., 90-151 Lodz, Poland.
Łukasz ChedaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warszawa, Poland.
Zbigniew RogulskiFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warszawa, Poland.
Paweł SzymańskiDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Medical University, 1 Muszynskiego St., 90-151 Lodz, Poland.ORCID 0000-0003-3438-7509
Ewa GniazdowskaCentre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland.ORCID 0000-0001-7446-1115
Instytut Chemii i Techniki Jądrowej · PLMedical University of Lodz · PLInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PLUniversity of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral pneumonia caused by highly infectious SARS-CoV-2 poses a higher risk to older people and those who have underlying health conditions, including Alzheimer's disease. In this work we present newly designed tacrine-based radioconjugates with physicochemical and biological properties that are crucial for the potential application as diagnostic radiopharmaceuticals. A set of ten tacrine derivatives was synthesized, labelled with gallium-68 and fully characterized in the context of their physicochemical properties. Based on these results, the final two most promising radioconjugates, [

Indexed as

Alzheimer DiseaseCOVID-19AcetylcholinesteraseAgedGallium RadioisotopesHumansRadiopharmaceuticalsSARS-CoV-2TacrineTissue DistributionAcetylcholinesteraseGallium RadioisotopesRadiopharmaceuticalsTacrinebiodistribution studiesCOVID-19gallium-68molecular dockingradiopharmaceuticalstacrine

Identifiers

PMID35955536
PMCPMC9369300
OpenAlexW4289135174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.