SynthesisInternational journal of environmental research and public health2022
The Risk for Neonatal Hypoglycemia and Bradycardia after Beta-Blocker Use during Pregnancy or Lactation: A Systematic Review and Meta-Analysis.
Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Antihypertensive therapy for pregnancy hypertension and implications for fetal and neonatal heart rate monitoring: A systematic review of randomized trials and observational studies.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Oral dextrose gel to prevent hypoglycaemia in at-risk neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Beta-blockers aren't the true "blockers" in pregnancy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Takotsubo Syndrome After Emergency Cesarean Delivery in Twin Pregnancy: A Rare Cause of Acute Postpartum Heart Failure.Case reports in obstetrics and gynecology · 2026Article
- Risk Factors Associated with Early and Late Postoperative Complications in Neonatal Patients with Esophageal Atresia.Children (Basel, Switzerland) · 2025Article
- Effect of maternal beta-blocker treatment on mean fetal heart rate.AJOG global reports · 2025Article
- Management of cardiopulmonary bypass in pregnancy: challenges and progress in maternal-fetal protection.Frontiers in cardiovascular medicine · 2025Review
- What Do We Know about Peripartum Cardiomyopathy? Yesterday, Today, Tomorrow.International journal of molecular sciences · 2024Review
- Effectiveness and safety of intravenous labetalol in severe pre-eclampsia and eclampsia at a teaching institution in Chhattisgarh.Journal of family medicine and primary care · 2024Article
- Considering Adverse Effects of Common Antihypertensive Medications in the ED.Current hypertension reports · 2024Review
- Development of a prediction model for neonatal hypoglycemia risk factors: a retrospective study.Frontiers in endocrinology · 2023Article
- Neonatal hypoglycemia: lack of evidence for a safe management.Frontiers in endocrinology · 2023Review
- Pharmacotherapy during Pregnancy, Childbirth, and Lactation.International journal of environmental research and public health · 2022Article
- Favorable outcome of fetal bradyarrhythmia: Two case reports and literature review.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beta-blockers are often used during pregnancy to treat cardiovascular diseases. The described neonatal side effects of maternal beta-blocker use are hypoglycemia and bradycardia, but the evidence base for these is yet to be evaluated comprehensively. Hence, this systematic review and meta-analysis was performed to evaluate the potential increased risk for hypoglycemia and bradycardia in neonates exposed to beta-blockers in utero or during lactation. A systematic search of English-language human studies was conducted until 21 April 2021. Both observational studies and randomized controlled trials investigating hypoglycemia and/or bradycardia in neonates following beta-blocker exposure during pregnancy and lactation were included. All articles were screened by two authors independently and eligible studies were included. Pair-wise and proportion-based meta-analysis was conducted and the certainty of evidence (CoE) was performed by standard methodologies. Of the 1.043 screened articles, 55 were included in this systematic review. Our meta-analysis showed a probable risk of hypoglycemia (CoE-Moderate) and possible risk of bradycardia (CoE-Low) in neonates upon fetal beta-blocker exposure. Therefore, we suggest the monitoring of glucose levels in exposed neonates until 24 h after birth. Due to the limited clinical implication, monitoring of the heart rate could be considered for 24 h. We call for future studies to substantiate our findings.
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