Evidence map›Paper›PMID 35954399›Full record

ArticleCancers2022

Pan-Cancer Analysis Reveals SH3TC2 as an Oncogene for Colorectal Cancer and Promotes Tumorigenesis via the MAPK Pathway.

Chengzhi Huang, Hui Yi, Yue Zhou, Qing Zhang, Xueqing Yao

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Identification ofBiomedicines · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chengzhi HuangSchool of Medicine, South China University of Technology, Guangzhou 510006, China.
Hui YiDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Yue ZhouDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Qing ZhangDepartment of General Surgery, Guangdong Provincial People's Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, China.
Xueqing YaoSchool of Medicine, South China University of Technology, Guangzhou 510006, China.ORCID 0000-0003-0570-7585
Ganzhou People's Hospital · CN

Funding

Guangdong Provincial People's Hospital DFJH201913Medical Scientific Research Foundation of Guangdong Province A2020019National key Clinical Specialty Construction Project (2021-2024) 2022YW030009Research Fund of CSCO-Haosen Oncology Y-HS2019/2-050Research Fund of CSCO-Roche Oncology Y-2019Roche-190Science and Technology Planning Project of Ganzhou 202101074816Science and Technology Plan of Guangzhou 202102080230
6 · The paper itself

Abstract

SH3 domain and tetrapeptide repeat 2 (SH3TC2) is a protein-encoding gene and has previously been described as a critical signaling hub for neurological disorders. Although increasing evidence supports a vital role of SH3TC2 in the tumorigenesis of various kinds of cancer, no systematic analysis of SH3TC2 is available. The function and mechanism of

Indexed as

colorectal cancerMAPK pathwaypan-cancer analysisSH3TC2tumorigenesis

Identifiers

PMID35954399
PMCPMC9367385
OpenAlexW4289109394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.