Evidence map›Paper›PMID 35954362›Full record

ReviewCancers2022

Immunology Meets Bioengineering: Improving the Effectiveness of Glioblastoma Immunotherapy.

Zahra Fekrirad, Amir Barzegar Behrooz, Shokoofeh Ghaemi, Arezou Khosrojerdi, Atefeh Zarepour, Ali Zarrabi, Ehsan Arefian, Saeid Ghavami

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Current Status and Evolution of Immunotherapy in Glioma Management.International journal of medical sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Immunotherapy in Glioblastoma: An Overview of Current Status.Clinical pharmacology : advances and applications · 2025
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zahra FekriradDepartment of Biology, Faculty of Basic Sciences, Shahed University, Tehran 18735-136, Iran.
Amir Barzegar BehroozBrain Cancer Research Group, Department of Cancer, Asu Vanda Gene Industrial Research Company, Tehran 1533666398, Iran.ORCID 0000-0002-8113-5809
Shokoofeh GhaemiDepartment of Microbiology, School of Biology, College of Science, University of Tehran, Tehran 14155-6619, Iran.
Arezou KhosrojerdiCellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand 9717853577, Iran.
Atefeh ZarepourDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Turkey.ORCID 0000-0002-0347-5840
Ali ZarrabiDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Turkey.ORCID 0000-0003-0391-1769
Ehsan ArefianDepartment of Microbiology, School of Biology, College of Science, University of Tehran, Tehran 14155-6619, Iran.ORCID 0000-0002-0758-4710
Saeid GhavamiFaculty of Medicine in Zabrze, University of Technology in Katowice, Academia of Silesia, 41-800 Zabrze, Poland.ORCID 0000-0001-5948-508X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) therapy has seen little change over the past two decades. Surgical excision followed by radiation and chemotherapy is the current gold standard treatment. Immunotherapy techniques have recently transformed many cancer treatments, and GBM is now at the forefront of immunotherapy research. GBM immunotherapy prospects are reviewed here, with an emphasis on immune checkpoint inhibitors and oncolytic viruses. Various forms of nanomaterials to enhance immunotherapy effectiveness are also discussed. For GBM treatment and immunotherapy, we outline the specific properties of nanomaterials. In addition, we provide a short overview of several 3D (bio)printing techniques and their applications in stimulating the GBM microenvironment. Lastly, the susceptibility of GBM cancer cells to the various immunotherapy methods will be addressed.

Indexed as

autophagyglioblastomaimmunotherapynanomedicinenanoparticlesoncolytic virotherapy

Identifiers

PMID35954362
PMCPMC9367505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.