Evidence map›Paper›PMID 35954358›Full record

ArticleCancers2022

RETRACTED: HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association.

Zheng Zhou, Qian Liu, Gehou Zhang, Diab Mohammed, Sani Amadou, Guolin Tan, Xiaowei Zhang

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. FRA-1 as a Regulator of EMT and Metastasis in Breast Cancer.International journal of molecular sciences · 2023
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zheng ZhouDepartment of Otolaryngology Head & Neck, Third Xiangya Hospital, Changsha 410013, China.
Qian LiuDepartment of Otolaryngology Head & Neck, Third Xiangya Hospital, Changsha 410013, China.
Gehou ZhangDepartment of Otolaryngology Head & Neck, Third Xiangya Hospital, Changsha 410013, China.
Diab MohammedDepartment of Otolaryngology Head & Neck, Xiangya Hospital, Changsha 410008, China.
Sani AmadouDepartment of ENT, Reference Hospital, Maradi 12481, Niger.
Guolin TanDepartment of Otolaryngology Head & Neck, Third Xiangya Hospital, Changsha 410013, China.
Xiaowei ZhangDepartment of Otolaryngology Head & Neck, Third Xiangya Hospital, Changsha 410013, China.ORCID 0000-0003-0197-001X
Central South University · CN

Funding

Hunan Youth Talents Project 2020
6 · The paper itself

Abstract

backgroundThe metastatic characteristics of hypopharyngeal squamous cell carcinoma (HSCC) lead to many diagnostic and therapeutic challenges, while functional long non-coding RNAs (lncRNAs) can provide effective strategies for its diagnosis and treatment.

methodsRT-qPCR, Western blot, immunohistochemistry, and an immunofluorescence assay were used to detect the related gene expression. Flow cytometry was used to measure the percentage of CD8

resultsHOXA11-AS1, PD-L1, and FOSL1 were upregulated in HSCC, and HOXA11-AS1 positively correlated with PD-L1. HOXA11-AS1 knockdown upregulated CD8

conclusionHOXA11-AS1 promoted PD-L1 expression by upregulating FOSL1 levels through PTBP1, thereby facilitating immune escape, proliferation, and metastasis of HSCC cells.

Indexed as

FOSL1HOXA11-AS1hypopharyngeal squamous cell carcinomaimmune escapePD-L1PTBP1

Identifiers

PMID35954358
PMCPMC9367556
OpenAlexW4289111723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.