Evidence map›Paper›PMID 35954332›Full record

ArticleCancers2022

Quincy C C van den Bosch, Josephine Q N Nguyen, Tom Brands, Thierry P P van den Bosch, Robert M Verdijk, Dion Paridaens, Nicole C Naus, Annelies de Klein, Emine Kiliç, Erwin Brosens and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Heliyon · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Quincy C C van den BoschDepartment of Ophthalmology, Erasmus MC Cancer Center, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Josephine Q N NguyenDepartment of Ophthalmology, Erasmus MC Cancer Center, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-6428-6226
Tom BrandsDepartment of Ophthalmology, Erasmus MC Cancer Center, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Thierry P P van den BoschDepartment of Pathology, Section Ophthalmic Pathology, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-7223-4565
Robert M VerdijkDepartment of Pathology, Section Ophthalmic Pathology, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0003-1437-214X
Dion ParidaensThe Rotterdam Eye Hospital, 3011 BH Rotterdam, The Netherlands.ORCID 0000-0001-6762-3614
Nicole C NausDepartment of Ophthalmology, Erasmus MC Cancer Center, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Annelies de KleinDepartment of Clinical Genetics, Erasmus MC Cancer Center, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Emine KiliçDepartment of Ophthalmology, Erasmus MC Cancer Center, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Erwin BrosensDepartment of Clinical Genetics, Erasmus MC Cancer Center, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8235-4010
Rotterdam Ocular Melanoma Study Group
Erasmus MC Cancer Institute · NLLeiden University Medical Center · NLRotterdam Eye Hospital · NL

Funding

Algemene Nederlandse Vereniging ter Voorkoming van Blindheid 2019-7Combined Ophthalmic Research Rotterdam 5.2.0Henkes Stichting 2021-04Landelijke Stichting voor Blinden en Slechtzienden 2019-7Rotterdamse Blindenbelang HV/AB/ B20200043
6 · The paper itself

Abstract

Uveal melanoma (UM) is a deadly ocular malignancy, originating from uveal melanocytes. Although much is known regarding prognostication in UM, the exact mechanism of metastasis is mostly unknown. Metastatic tumor cells are known to express a more stem-like RNA profile which is seen often in cell-specific embryonic development to induce tumor progression. Here, we identified novel transcription regulators by reanalyzing publicly available single cell RNA sequencing experiments. We identified five transcription regulators of interest:

Indexed as

in silico analysismelanocyte developmenttranscription factor

Identifiers

PMID35954332
PMCPMC9367502
OpenAlexW4288445690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.