ReviewCancers2022
Leydig Cell Tumors of the Testis: An Update of the Imaging Characteristics of a Not So Rare Lesion.
Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Contrast-enhanced ultrasonography vs MRI for indeterminate testicular lesions: a systematic review and meta-analysis.BJU international · 2026Pooled it
- Bilateral Leydig Cell Tumor in a Capuchin Monkey (Sapajus apella): Case Report.Journal of medical primatology · 2026Article
- Multimodal Ultrasound Characterization of a Testicular Leydig Cell Tumor With Emphasis on Microvascular Flow Imaging Findings: A Case Report and Literature Review.Journal of clinical ultrasound : JCU · 2026Review
- A Case of a Rare Testicular Tumor With Synchronous Malignancy.IJU case reports · 2026Article
- Metastatic Leydig cell tumor: A case report and review of the literature.Urology case reports · 2026Article
- Ten-year indolent evolution of a Leydig cell tumor: A case report and literature review.Urology case reports · 2026Article
- Colour Doppler Ultrasonography in the Assessment of Intratesticular Lesions: Influence of Lesion Size and Vascular Pattern.Cancers · 2026Article
- Testicular intestinal-type adenocarcinoma without an identifiable extratesticular primary site: a case report and literature review.Frontiers in oncology · 2026Article
- Combination treatment of cordycepin and radiation induces apoptosis accompanied by protective autophagy in TM3 mouse Leydig progenitor cells.Journal of food and drug analysis · 2025Article
- MRI of the Scrotum and Penis: Current Applications and Clinical Relevance.Diagnostics (Basel, Switzerland) · 2025Review
- Simvastatin-Mediated Molecular Mechanisms Underlying the Growth Inhibition of Testicular Leydig Tumour Cells.Journal of cellular and molecular medicine · 2025Article
- Unilateral pubic hair growth: a paracrine finding indicative of underlying leydig cell tumor in a prepubertal boy.Urology case reports · 2025Article
- The Coincidence of Ovarian Endometrioma with Paratubal Leydig Cell Nodules: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Shear Wave Elastography Evaluation of Testicular Stiffness in Dogs Affected by Testicular Pathology.Animals : an open access journal from MDPI · 2025Article
- Updates on Imaging of Common Urogenital Neoplasms.Cancers · 2024Article
- Multiparametric Ultrasound for Focal Testicular Pathology: A Ten-Year Retrospective Review.Cancers · 2024Article
- Multiparametric Ultrasound for Diagnosing Testicular Lesions: Everything You Need to Know in Daily Clinical Practice.Cancers · 2023Review
- Sonoelastography for Testicular Tumor Identification: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy.Cancers · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-operative testicular tumor characterization is a challenge for radiologists and urologists. New data concerning imaging approaches or immunochemistry markers improve the management of patients presenting with a testicular tumor, sometimes avoiding radical orchiectomy. In the past 20 years, imaging modalities, especially ultrasound (US) and magnetic resonance imaging (MRI), improved, allowing for great progress in lesion characterization. Leydig cell tumors (LCT) are rare testicular tumors developing from the stromal tissue, with relatively scarce literature, as most of the studies focus on the much more frequent germ cell tumors. However, with the increase in testicular sonography numbers, the incidence of LCT appears much higher than expected, with some studies reporting up to 22% of small testicular nodules. Multimodal ultrasound using Doppler, Elastography, or injection of contrast media can provide crucial arguments to differentiate LCT from germ cell tumors. Multiparametric MRI is a second intention exam, but it allows for extraction of quantifiable data to assess the diagnosis of LCT. The aims of this article are to review the latest data regarding LCT imaging features, using multimodal ultrasound and multiparametric MRI, and to focus on the peculiar aspect of the testis of patients with Klinefelter's syndrome. The possibility of an LCT should be raised in front of a small hypoechoic tumor with a marked corbelling hypervascularization in an otherwise normal testicular pulp. Ultrasonographic modules, such as ultrasensitive Doppler, contrast-enhanced ultrasonography, or elastography, can be used to reinforce the suspicion of LCT. MRI provides objective data regarding vascularization and enhancement kinetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.