Evidence map›Paper›PMID 35954278›Full record

ReviewCells2022

Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis.

Malavikalakshmi Attur, Jose U Scher, Steven B Abramson, Mukundan Attur

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Anti-Inflammatory Potential ofMicroorganisms · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Biomolecules · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. [Tujia medicineNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Malavikalakshmi AtturDrexel University College of Medicine, Drexel University, Philadelphia, PA 19129, USA.
Jose U ScherDivision of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, NY 10003, USA.
Steven B AbramsonDivision of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, NY 10003, USA.
Mukundan AtturDivision of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, NY 10003, USA.ORCID 0000-0001-7080-8118
New York University · US

Funding

Micro-TeACH (Microbiome Technology and Analytic Center Hub)UC2AR081034 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jose C Clemente, ADRIANA HEGUY · 2022 to 2026
$4.6M
Employing the gut microbiome to accelerate effective initiation of rheumatoid arthritis therapyR01AR074500 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Renuka Rajendra Nayak, Jose U. Scher · 2019 to 2026
$4.1M
NIAMS NIH HHS R01 AR074500NIAMS NIH HHS UC2 AR081034
6 · The paper itself

Abstract

Rheumatoid arthritis is a chronic systemic immune-mediated disease caused by genetic and environmental factors. It is often characterized by the generation of autoantibodies that lead to synovial inflammation and eventual multi-joint destruction. A growing number of studies have shown significant differences in the gut microbiota composition of rheumatoid arthritis (RA) patients compared to healthy controls. Environmental factors, and changes in diet and nutrition are thought to play a role in developing this dysbiosis. This review aims to summarize the current knowledge of intestinal dysbiosis, the role of nutritional factors, and its implications in the pathogenesis of rheumatoid arthritis and autoimmunity. The future direction focuses on developing microbiome manipulation therapeutics for RA disease management.

Indexed as

Arthritis, RheumatoidGastrointestinal MicrobiomeMicrobiotaAutoimmunityDysbiosisHumansarthritisdysbiosismicrobiomenutrition

Identifiers

PMID35954278
PMCPMC9368368
OpenAlexW4290466233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.