Evidence map›Paper›PMID 35954259›Full record

ArticleCells2022

Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca

Monika I Hollenhorst, Praveen Kumar, Maxim Zimmer, Alaa Salah, Stephan Maxeiner, Mohamed Ibrahem Elhawy, Saskia B Evers, Veit Flockerzi, Thomas Gudermann, Vladimir Chubanov and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Identification of Bitter Peptides inFoods (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Tuft cell-derived acetylcholine regulates epithelial fluid secretion.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Monika I HollenhorstInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
Praveen KumarInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
Maxim ZimmerInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
Alaa SalahInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
Stephan MaxeinerInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.ORCID 0000-0002-4472-695X
Mohamed Ibrahem ElhawyInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.ORCID 0000-0002-8252-1832
Saskia B EversInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
Veit FlockerziInstitute for Experimental and Clinical Pharmacology and Toxicology, Centre for Molecular Signalling, Saarland University, 66421 Homburg, Germany.
Thomas GudermannWalter-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University and German Centre for Lung Research (DZL), 80366 Munich, Germany.
Vladimir ChubanovWalter-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University and German Centre for Lung Research (DZL), 80366 Munich, Germany.ORCID 0000-0002-6042-4193
Ulrich BoehmExperimental Pharmacology, Centre for Molecular Signalling, School of Medicine, Saarland University, 66421 Homburg, Germany.ORCID 0000-0003-2436-6907
Gabriela Krasteva-ChristInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
Saarland University · DEGerman Center for Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucociliary clearance is a primary defence mechanism of the airways consisting of two components, ciliary beating and transepithelial ion transport (I

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorTaste BudsAnimalsCyclic AMPEpithelial Sodium ChannelsMiceQuaternary Ammonium CompoundsTasteCyclic AMPCystic Fibrosis Transmembrane Conductance RegulatordenatoniumEpithelial Sodium ChannelsQuaternary Ammonium CompoundsAChairway epitheliumbrush cellCFTRENaCion transportmucociliary clearanceTrpm5Ussing chamber

Identifiers

PMID35954259
PMCPMC9367940
OpenAlexW4289985851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.