Evidence map›Paper›PMID 35954237›Full record

ArticleCells2022

Endogenous Retroviral Sequences Behave as Putative Enhancers Controlling Gene Expression through HP1-Regulated Long-Range Chromatin Interactions.

Sébastien Calvet, Séphora Sallis, Nehmé Saksouk, Cosette Rebouissou, Catherine Teyssier, Annick Lesne, Florence Cammas, Thierry Forné

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sébastien CalvetInstitut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, Inserm U1194, ICM, CNRS, F-34298 Montpellier, France.
Séphora SallisInstitut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS, F-34293 Montpellier, France.
Nehmé SaksoukInstitut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, Inserm U1194, ICM, CNRS, F-34298 Montpellier, France.
Cosette RebouissouInstitut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS, F-34293 Montpellier, France.
Catherine TeyssierInstitut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, Inserm U1194, ICM, CNRS, F-34298 Montpellier, France.ORCID 0000-0003-4937-6503
Annick LesneInstitut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS, F-34293 Montpellier, France.
Florence CammasInstitut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, Inserm U1194, ICM, CNRS, F-34298 Montpellier, France.
Thierry FornéInstitut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS, F-34293 Montpellier, France.ORCID 0000-0002-9179-1551
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About half of the mammalian genome is constituted of repeated elements, among which endogenous retroviruses (ERVs) are known to influence gene expression and cancer development. The HP1 (Heterochromatin Protein 1) proteins are known to be essential for heterochromatin establishment and function and its loss in hepatocytes leads to the reactivation of specific ERVs and to liver tumorigenesis. Here, by studying two ERVs located upstream of genes upregulated upon loss of HP1,

Indexed as

Endogenous RetrovirusesAnimalsChromatinChromobox Protein Homolog 5Gene ExpressionHeterochromatinMammalsChromatinChromobox Protein Homolog 5Heterochromatinchromatin organizationendogenous retrovirusesHP1Trim24

Identifiers

PMID35954237
PMCPMC9368123
OpenAlexW4289704989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.