Evidence map›Paper›PMID 35954234›Full record

ArticleCells2022

Pre-Synaptic GABA

Sheng Liu, Veronica Bonalume, Qi Gao, Jeremy Tsung-Chieh Chen, Karl Rohr, Jing Hu, Richard Carr

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Sheng LiuDepartment of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China.ORCID 0000-0003-4981-8551
Veronica BonalumeDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0002-1185-2351
Qi GaoCore Facility Platform Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Jeremy Tsung-Chieh ChenCenter for Interdisciplinary Pain Medicine, Department of Anesthesiology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Karl RohrBiomedical Computer Vision Group, BioQuant, IPMB, Heidelberg University, 69120 Heidelberg, Germany.
Jing HuDepartment of Pharmacology, Heidelberg University, 69120 Heidelberg, Germany.
Richard CarrExperimental Pain Research, Mannheim Centre for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0001-8617-9133
Heidelberg University · DEUniversitätsklinikum Würzburg · DEUniversity of Milan · ITZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypersensitivity to mechanical stimuli is a cardinal symptom of neuropathic and inflammatory pain. A reduction in spinal inhibition is generally considered a causal factor in the development of mechanical hypersensitivity after injury. However, the extent to which presynaptic inhibition contributes to altered spinal inhibition is less well established. Here, we used conditional deletion of GABA

Indexed as

HyperalgesiaNociceptorsAnimalsFreund's Adjuvantgamma-Aminobutyric AcidInflammationMiceFreund's Adjuvantgamma-Aminobutyric Acidactivity-dependent slowingc-foselectrical excitabilityGABAANaV1.8presynaptic inhibitionpunctate mechanical allodyniaspinal dorsal horn

Identifiers

PMID35954234
PMCPMC9368720
OpenAlexW4289704818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.