ArticleCells2022
A Promising Method for the Determination of Cell Viability: The Membrane Potential Cell Viability Assay.
Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Predictive In Vitro Diagnostic Screening of Strontium-Enriched Biodegradable Mg-Ca Alloys for Emerging Dental Applications.Diagnostics (Basel, Switzerland) · 2026Article
- Combined In Vitro and Computational Investigations on Synthesized Sulfonamide-Based Antidiabetic Agents.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Antitumor-Directed Fractionation ofPharmaceuticals (Basel, Switzerland) · 2026Article
- How to Establish a Novel Liver Cell Culture System That Resembles the In Vivo Liver Microenvironment.Current protocols · 2025Article
- Tracking chondrocyte-to-fibroblast transformation via changes in cell electrophysiology.Scientific reports · 2025Article
- Automated cell properties toolbox from 3D bioprinted hydrogel scaffolds via deep learning and optical coherence tomography.Biomedical optics express · 2025Article
- An Overview of the Current State of Cell Viability Assessment Methods Using OECD Classification.International journal of molecular sciences · 2024Review
- Finding a Direct Method for a Dynamic Process: The DD (Direct and Dynamic) Cell-Tox Method.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the viability of cells is fraught with many uncertainties. It is often difficult to determine whether a cell is still alive, approaching the point of no return, or dead. Today, there are many methods for determining cell viability. Most rely on an indirect determination of cell death (metabolism, molecular transport, and leakage, to name a few). In contrast, we have developed a promising novel method for a "direct" determination of cell viability. The potential method assesses cell membrane integrity (which is essential for all viable cells) by measuring the electrical potential of the cell membrane. To test the assay, we chose two different cell types, blood macrophages (TLT) and breast cancer epithelial cells (MCF 7). We exposed them to seven different toxic scenarios (arsenic (V), UV light, hydrogen peroxide, nutrient starvation, Tetrabromobisphenol A, fatty acids, and 5-fluorouracil) to induce different cell death pathways. Under controlled test conditions, the assay showed good accuracy when comparing the toxicity assessment with well-established methods. Moreover, the method showed compatibility with live cell imaging. Although we know that further studies are needed to confirm the performance of the assay in other situations, the results obtained are promising for their wider application in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.