Evidence map›Paper›PMID 35953994›Full record

ReviewAnimals : an open access journal from MDPI2022

Of Elephants and Other Mammals: A Comparative Review of Reproductive Tumors and Potential Impact on Conservation.

Lisa M Abegglen, Tara M Harrison, Anneke Moresco, Jared S Fowles, Brigid V Troan, Wendy K Kiso, Dennis Schmitt, Amy M Boddy, Joshua D Schiffman

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lisa M AbegglenDepartment of Pediatrics & Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3607-3001
Tara M HarrisonArizona Cancer Evolution Center, Arizona State University, Tempe, AZ 85281, USA.ORCID 0000-0002-2072-5936
Anneke MorescoExotic Species Cancer Research Alliance, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA.ORCID 0000-0002-1525-1166
Jared S FowlesDepartment of Pediatrics & Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Brigid V TroanExotic Species Cancer Research Alliance, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA.ORCID 0000-0003-2212-2167
Wendy K KisoWhite Oak Conservation Foundation, Yulee, FL 32097, USA.
Dennis SchmittDepartment of Animal Science, William H. Darr College of Agriculture, Missouri State University, Springfield, MO 65809, USA.
Amy M BoddyArizona Cancer Evolution Center, Arizona State University, Tempe, AZ 85281, USA.
Joshua D SchiffmanDepartment of Pediatrics & Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-6968-7694
North Carolina State University · USMissouri State University · USUniversity of Utah · US

Funding

The Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO, SHIBATA, DARRYL K · 2018 to 2022
$8.6M
NCI NIH HHS U54 CA217376NIH HHS U54CA217376
6 · The paper itself

Abstract

Reproductive tumors can impact conception, pregnancy, and birth in mammals. These impacts are well documented in humans, while data in other mammals are limited. An urgent need exists to understand the reproductive impact of these lesions in endangered species, because some endangered species have a documented high prevalence of reproductive tumors. This article documents that the prevalence of both benign and malignant neoplasia differs between African and Asian elephants, with Asian elephants more frequently diagnosed and negatively affected by both. The prevalence of these tumors across mammalian species is compared, and impact plus treatment options in human medicine are reviewed to inform decision making in elephants. Evidence suggests that reproductive tumors can negatively impact elephant conservation. Future studies that document reproductive outcomes, including the success of various treatment approaches in elephants with tumors will benefit conservation efforts.

Indexed as

comparative oncologyElephas maximusfertilityfibroidleiomyomaLoxodonta africananeoplasiapreventiontreatmentuterine

Identifiers

PMID35953994
PMCPMC9367617
OpenAlexW4290703634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.