ArticleAnimals : an open access journal from MDPI2022
Dietary Protected Butyrate Supplementation of Broilers Modulates Intestinal Tight Junction Proteins and Stimulates Endogenous Production of Short Chain Fatty Acids in the Caecum.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
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- Effects ofAnimals : an open access journal from MDPI · 2026Article
- Effects of Different Levels of Licorice Residue and Sweet Sorghum on Pellet Feed Quality, Intestinal Morphology, Cecal Volatile Fatty Acids, and Microorganisms in Meat Rabbits.Microorganisms · 2026Article
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- Quantum dot butyrate: a novel strategy to improve performance, nutrient digestibility and gut barrier function in broilers.BMC veterinary research · 2026Article
- Butyric, lactic, and propionic acids with their salts as natural growth promoters in broilers.Scientific reports · 2025Article
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- Dietary jack bean (Heliyon · 2024Article
- Article
- Dietary xylo-oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens.Journal of animal science and biotechnology · 2024Article
- Effects of Dietary Microcapsule Sustained-Release Sodium Butyrate on the Growth Performance, Immunity, and Gut Microbiota of Yellow Broilers.Animals : an open access journal from MDPI · 2023Article
- Article
- Midgut microbiota affects the intestinal barrier by producing short-chain fatty acids inFrontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short chain fatty acid (SCFA) butyrate has various beneficial effects on the gut microbiota as well as on the overall health status and metabolism of the host organism. The modulatory role of butyrate on gut barrier integrity reflected by tight junction protein expression has been already described in mammalian species. However, there is limited information available regarding chickens. Therefore, the main aim of this study was to monitor the effects of protected butyrate on claudin barrier protein and monocarboxylate transporter 1 abundance in different gastrointestinal segments of chickens as well as the growth performance of broiler chickens. The effect of protected butyrate on the caecal microbiota was monitored by quantifying the concentrations of total eubacteria and key enzymes of butyrate production. Furthermore, intestinal SCFA concentrations were also measured. Based on the data obtained, protected butyrate increased the overall performance as well as the barrier integrity of various gut segments. Protected butyrate also positively affected the SCFA concentration and composition. These findings provide valuable insight into the complex effects of protected butyrate on broiler gut health, highlighting the beneficial effects in improving intestinal barrier integrity and performance parameters.
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Registered trials
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