Evidence map›Paper›PMID 35953883›Full record

ArticleEuropean journal of cancer care2022

Feasibility of a supervised and home-based tailored exercise intervention in head and neck cancer patients during chemoradiotherapy.

Annemieke Kok, Ellen Passchier, Anne M May, Michiel W M van den Brekel, Harriët Jager-Wittenaar, Cindy Veenhof, Remco de Bree, Martijn M Stuiver, Caroline M Speksnijder

Open access · hybridAbstract read
In one paragraph

Article in European journal of cancer care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
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  3. Feasibility of a comprehensive supervised exercise program during and after treatment of head and neck cancer: a mixed-methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  13. Development and Feasibility of CALORIE CAREIndian journal of palliative care
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Annemieke KokDepartment of Dietetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-5612-3558
Ellen PasschierDepartment of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, Netherlands.ORCID https://orcid.org/0000-0002-5191-3155
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID https://orcid.org/0000-0001-7551-9200
Michiel W M van den BrekelDepartment of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, Netherlands.ORCID https://orcid.org/0000-0002-6338-6743
Harriët Jager-WittenaarDepartment of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0003-3928-8075
Cindy VeenhofDepartment of Rehabilitation, Physiotherapy Science and Sports, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID https://orcid.org/0000-0003-0970-2896
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID https://orcid.org/0000-0001-7128-5814
Martijn M StuiverDepartment of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, Netherlands.ORCID https://orcid.org/0000-0002-7794-7767
Caroline M SpeksnijderDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID https://orcid.org/0000-0003-0540-3741
Utrecht University · NLThe Netherlands Cancer Institute · NLDutch Cancer Society · NLUniversity Medical Center Groningen · NLUniversity of Applied Sciences Utrecht · NL

Funding

World Cancer Research Fund International 2016/1632
6 · The paper itself

Abstract

objectiveChemoradiotherapy (CRT) for head and neck cancer (HNC) is associated with high toxicity that adversely affects physical functioning, body composition, fatigue, quality of life and treatment outcomes. Exercise interventions during treatment might counteract these negative effects. We therefore assessed the feasibility of an exercise programme for HNC patients during CRT.

methodsForty patients were offered a tailored 10-week endurance and resistance training with supervised and home-based sessions. Feasibility endpoints were (1) adherence (main outcome): ≥60% attendance; (2) recruitment: ≥30%; (3) retention rate: ≥85% and (4) compliance rate: ≥60%. Physical performance, muscle strength, body composition, quality of life and fatigue were assessed pre- and post-intervention.

resultsOverall adherence was 54%. The recruitment rate was 36%, and the retention rate was 65%. Compliance to the supervised intervention protocol was 66%. Statistically significant decreases were found in mean grip strength, fat-free mass and clinically relevant deteriorations on several domains of quality of life, and fatigue subscales were found.

conclusionWe conclude that this exercise programme for HNC patients during CRT in its current form is feasible for only a minority of patients. We suggest adaptations to improve adherence and retention rates for a definitive multicentre trial.

trial registrationThis study is registered at the Netherlands Trial Register (NTR7305), 6 June 2018, retrospectively registered.

Indexed as

Exercise TherapyHead and Neck NeoplasmsBody CompositionChemoradiotherapyFatigueFeasibility StudiesHand StrengthHumansPatient CompliancePhysical Functional PerformanceQuality of Lifechemoradiotherapyendurance trainingexercise interventionfeasibility studyhead and neck cancerresistance training

Identifiers

PMID35953883
PMCPMC9787293
OpenAlexW4293013234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.