Evidence map›Paper›PMID 35953878›Full record

Trial reportAlcoholism, clinical and experimental research2022

Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning-after effects.

Elisa Pabon, Ian M Greenlund, Jason R Carter, Harriet de Wit

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Cardiovascular and aortic wave reflection responses to evening binge alcohol consumption.American journal of physiology. Heart and circulatory physiology · 2025
    Trial
  3. Trial
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elisa PabonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-6669-7259
Ian M GreenlundDepartment of Psychology, Montana State University, Bozeman, Montana, USA.
Jason R CarterDepartment of Psychology, Montana State University, Bozeman, Montana, USA.
Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
Montana State University · USUniversity of Chicago · US

Funding

University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469 · NIDA · UNIVERSITY OF CHICAGO · PI Donald Hedeker, Xiaoxi Zhuang · 2017 to 2026
$3.8M
Alcohol and Neurovascular Control in HumansR01AA024892 · NIAAA · MONTANA STATE UNIVERSITY - BOZEMAN · PI CARTER, JASON R · 2017 to 2021
$1.8M
Differential female response to delta-9-tetrahydrocannabinol (THC)F31DA049391 · NIDA · UNIVERSITY OF CHICAGO · PI PABON, ELISA · 2020 to 2021
$92k
NIAAA NIH HHS R01 AA024892NIDA NIH HHS F31 DA049391NIDA NIH HHS T32 DA043469NIGMS NIH HHS R25 GM109439
6 · The paper itself

Abstract

backgroundAlcohol consumption produces feelings of well-being and stimulation, but also impairs psychomotor performance, disturbs cardiovascular function and sleep, and can disrupt next-day mood and behavior. A deeper understanding of how the acute effects of alcohol relate to its sleep and morning-after effects is needed to minimize harm resulting from its use. This study examined relationships between the effects of a high dose of alcohol on subjective and psychomotor measures, nocturnal heart rate, sleep quality, and morning-after mood and behavior. We hypothesized that alcohol would produce disturbances in cardiovascular and sleep regulation during the night, which would predict morning-after mood and behavioral performance.

methodsThirty-one men and women participated in two overnight laboratory visits during which they consumed either alcohol (1.0 g/kg for men, 0.85 g/kg for women) or placebo (randomized, crossover design). They consumed the beverage from 8 to 9 pm, and remained in the laboratory overnight for polysomnographic sleep recording. Subjective and behavioral measures were obtained during consumption and at 7-8 am the morning after.

resultsAlcohol increased both negative and positive arousal, urge to drink and sedation, and it impaired performance on behavioral tasks. During sleep, alcohol produced expected tachycardia and detriments in sleep quality including decreased total sleep time, sleep efficiency, and altered sleep architecture. Only modest effects on mood or performance were detected the following morning. The acute sedative-like effects of alcohol were related to increases in N2 sleep, but not to other disruptions in sleep or nocturnal heart rate, and neither sleep impairments nor nocturnal heart rate were related to mood or task performance the morning after.

conclusionsThe effects of alcohol on sleep and nocturnal heart rate were not strongly related to either its acute or morning-after effects. These findings do not provide strong support for the idea that alcohol-induced sleep disruptions underlie morning-after effects.

Indexed as

Psychomotor PerformanceSleepAffectCross-Over StudiesEthanolFemaleHeart RateHumansHypnotics and SedativesMaleEthanolHypnotics and Sedativesalcoholhyperarousalmorning-afterREMsleep

Identifiers

PMID35953878
PMCPMC9826048
OpenAlexW4293201453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.