Evidence map›Paper›PMID 35953874›Full record

ArticleBMC research notes2022

Whole-body inhalation of nano-sized carbon black: a surrogate model of military burn pit exposure.

Janeen H Trembley, Simon W So, Joshua P Nixon, Elizabeth C Bowdridge, Krista L Garner, Julie Griffith, Kevin J Engles, Thomas P Batchelor, William T Goldsmith, Julie M Tomáška and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Military burn pit exposure and airway disease: Implications for our Veteran population.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Janeen H TrembleyMinneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Simon W SoMinneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Joshua P NixonMinneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Elizabeth C BowdridgeDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Krista L GarnerDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Julie GriffithDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Kevin J EnglesDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Thomas P BatchelorDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
William T GoldsmithDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Julie M TomáškaBurn Pits 360 Veterans Organization, Robstown, TX, USA.
Salik HussainDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Timothy R Nurkiewicz *Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Tammy A Butterick *Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA. butte017@umn.edu.ORCID http://orcid.org/0000-0001-8516-0385
West Virginia University · USUniversity of Minnesota · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
Remote Microvascular Dysfunction After Particulate Matter ExposureR01ES015022 · NIEHS · WEST VIRGINIA UNIVERSITY · PI NURKIEWICZ, TIMOTHY R · 2007 to 2021
$4.9M
Stroke and Alzheimers Disease Related DementiasT32AG052375 · NIA · WEST VIRGINIA UNIVERSITY · PI Paul D Chantler, BERNARD G. SCHREURS · 2017 to 2026
$3.5M
Inflammatory cross-talk between heat events and air pollutionR01ES031253 · NIEHS · WEST VIRGINIA UNIVERSITY · PI HUSSAIN, SALIK · 2020 to 2024
$3.5M
Pre-doctoral Training in Systems ToxicologyT32ES032920 · NIEHS · WEST VIRGINIA UNIVERSITY · PI Timothy R Nurkiewicz · 2022 to 2026
$1.2M
Impact of Obesity on Brain Immune Response and CognitionI01BX004146 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI Tammy Angaline Butterick · 2019 to 2026
–
BLRD VA I01 BX004146NIA NIH HHS T32 AG052375NIEHS NIH HHS R01 ES015022NIEHS NIH HHS R01 ES031253NIEHS NIH HHS T32 ES032920NIGMS NIH HHS U54 GM104942NIH HHS R01 ES015022NIH HHS R01 ES031253NIH HHS WV-CTSI U54 GM104942-05
6 · The paper itself

Abstract

objectiveChronic multisymptom illness (CMI) is an idiopathic disease affecting thousands of U.S. Veterans exposed to open-air burn pits emitting aerosolized particulate matter (PM) while serving in Central and Southwest Asia and Africa. Exposure to burn pit PM can result in profound biologic consequences including chronic fatigue, impaired cognition, and respiratory diseases. Dysregulated or unresolved inflammation is a possible underlying mechanism for CMI onset. We describe a rat model of whole-body inhalation exposure using carbon black nanoparticles (CB) as a surrogate for military burn pit-related exposure. Using this model, we measured biomarkers of inflammation in multiple tissues.

resultsMale Sprague Dawley rats were exposed to CB aerosols by whole body inhalation (6 ± 0.83 mg/m

Indexed as

IncinerationSootAnimalsBiomarkersCarbonChronic DiseaseInflammationInhalation ExposureLungMaleRatsRats, Sprague-DawleyBiomarkersCarbonSootBurn Pit ExposureCarbon BlackChronic Multisymptom IllnessCytokinesEnvironmental ExposureInflammationInhalation toxicologyNanoparticle

Identifiers

PMID35953874
PMCPMC9373276
OpenAlexW4291818822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.