Evidence map›Paper›PMID 35953854›Full record

SynthesisAntimicrobial resistance and infection control2022

Risk of transmission of respiratory viruses during aerosol-generating medical procedures (AGMPs) revisited in the COVID-19 pandemic: a systematic review.

Jenine Leal, Brenlea Farkas, Liza Mastikhina, Jordyn Flanagan, Becky Skidmore, Charleen Salmon, Devika Dixit, Stephanie Smith, Stephen Tsekrekos, Bonita Lee and 10 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Antimicrobial resistance and infection control, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Revisiting the personal protective equipment components of transmission-based precautions for the prevention of COVID-19 and other respiratory virus infections in healthcare.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  10. Article
  11. Evaluation for the Presence of SARS-CoV-2 in COJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Jenine LealInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada. Jenine.leal@ucalgary.ca.
Brenlea FarkasHealth Technology Assessment Unit, University of Calgary, Calgary, AB, Canada.
Liza MastikhinaHealth Technology Assessment Unit, University of Calgary, Calgary, AB, Canada.
Jordyn FlanaganHealth Technology Assessment Unit, University of Calgary, Calgary, AB, Canada.
Becky SkidmoreHealth Technology Assessment Unit, University of Calgary, Calgary, AB, Canada.
Charleen SalmonDepartment of Community Health Sciences, University of Calgary, Calgary, AB, Canada.
Devika DixitDepartment of Pediatrics, University of Calgary and Alberta Health Services, Calgary, AB, Canada.
Stephanie SmithInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
Stephen TsekrekosDepartment of Medicine (Infectious Diseases), University of Alberta, Edmonton, AB, Canada.
Bonita LeeInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
Joseph VayalumkalInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
Jessica DunnDepartment of Pediatrics, University of Calgary and Alberta Health Services, Calgary, AB, Canada.
Robyn HarrisonDepartment of Medicine (Infectious Diseases), University of Alberta, Edmonton, AB, Canada.
Melody CordovizInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
Roberta DuboisProvincial Respiratory Services, Alberta Health Services, Edmonton, Canada.
Uma ChandranInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
Fiona ClementDepartment of Community Health Sciences, University of Calgary, Calgary, AB, Canada.
Kathryn BushInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
John ConlyInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
Oscar LariosInfection Prevention and Control, Alberta Health Services, Calgary, AB, Canada.
University of Calgary · CAAlberta Health Services · CAUniversity of Alberta · CAWorkplace Health, Safety and Compensation Commission · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn many jurisdictions healthcare workers (HCWs) are using respirators for aerosol-generating medical procedures (AGMPs) performed on adult and pediatric populations with all suspect/confirmed viral respiratory infections (VRIs). This systematic review assessed the risk of VRIs to HCWs in the presence of AGMPs, the role respirators versus medical/surgical masks have on reducing that risk, and if the risk to HCWs during AGMPs differed when caring for adult or pediatric patient populations. MAIN TEXT: We searched MEDLINE, EMBASE, Cochrane Central, Cochrane SR, CINAHL, COVID-19 specific resources, and MedRxiv for English and French articles from database inception to September 9, 2021. Independent reviewers screened abstracts using pre-defined criteria, reviewed full-text articles, selected relevant studies, abstracted data, and conducted quality assessments of all studies using the ROBINS-I risk of bias tool. Disagreements were resolved by consensus. Thirty-eight studies were included; 23 studies on COVID-19, 10 on SARS, and 5 on MERS/ influenza/other respiratory viruses. Two of the 16 studies which assessed associations found that HCWs were 1.7 to 2.5 times more likely to contract COVID-19 after exposure to AGMPs vs. not exposed to AGMPs. Eight studies reported statistically significant associations for nine specific AGMPs and transmission of SARS to HCWS. Intubation was consistently associated with an increased risk of SARS. HCWs were more likely (OR 2.05, 95% CI 1.2-3.4) to contract human coronaviruses when exposed to an AGMP in one study. There were no reported associations between AGMP exposure and transmission of influenza or in a single study on MERS. There was limited evidence supporting the use of a respirator over a medical/surgical mask during an AGMP to reduce the risk of viral transmission. One study described outcomes of HCWs exposed to a pediatric patient during intubation.

conclusionExposure to an AGMP may increase the risk of transmission of COVID-19, SARS, and human coronaviruses to HCWs, however the evidence base is heterogenous and prone to confounding, particularly related to COVID-19. There continues to be a significant research gap in the epidemiology of the risk of VRIs among HCWs during AGMPs, particularly for pediatric patients. Further evidence is needed regarding what constitutes an AGMP.

Indexed as

COVID-19Influenza, HumanChildHumansPandemicsRespiratory Aerosols and DropletsSARS-CoV-2Acute viral respiratory infectionAerosol-generating proceduresCOVID-19Healthcare workerSARSTransmission

Identifiers

PMID35953854
PMCPMC9366810
OpenAlexW4291017758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.