Evidence map›Paper›PMID 35953806›Full record

ArticleBMC ophthalmology2022

Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case-control study.

Yimin Zhang, Jing Feng, Shuming Shao, Qing Mu, Jie Liu, Chaomei Zeng, Xiaorui Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Systemic Cytokines in Retinopathy of Prematurity.Journal of personalized medicine · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yimin Zhang *Department of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China.
Jing Feng *Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Shuming ShaoDepartment of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China.
Qing MuDepartment of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing, China.
Jie LiuDepartment of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China.
Chaomei ZengDepartment of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China.
Xiaorui ZhangDepartment of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China. icy.zhang@163.com.
Peking University People's Hospital · CNCapital Medical University · CNPeking University · CN

Funding

National Natural Science Foundation-Beijing Hospitals Authority Youth No. QML20190303Peking University People's Hospital Research and Development Funds RDC 2015-21the Foundation of 2018 Beijing Key Clinical Specialty Construction Project-Pediatrics 2199000726
6 · The paper itself

Abstract

backgroundAlthough several clinical studies have analysed the relationship between the levels of vascular endothelial growth factor (VEGF) and apelin-13 in venous blood and retinopathy of prematurity (ROP), no definitive conclusions have been reached. This study aimed to investigate the relationship between apelin-13 levels and VEGF levels and ROP.

methodsDifferences in plasma apelin-13 and VEGF levels were analysed in two groups of infants born with birth weight < 1500 g and gestational age < 32 weeks at Peking University People' s Hospital. One group comprised infants diagnosed with ROP and the other group was a control group comprising infants without ROP.

resultsApelin-13 levels were significantly lower in the ROP group than in the control group, while VEGF levels showed the opposite result (both P < 0.001). Infants with severe ROP had lower apelin-13 levels and higher VEGF levels than with mild ROP (both P < 0.05).The receiver operating characteristic curve for apelin-13 level as the indicator of ROP showed that a cut-off value of 119.6 pg/mL yielded a sensitivity of 84.8% and a specificity of 63.6%, while for VEGF level, the cut-off value of 84.3 pg/mL exhibited a sensitivity of 84.8% and a specificity of 66.7%.

conclusionsPlasma apelin-13 and VEGF levels at 4-6 weeks of age may play a role in assisting the diagnosis of ROP.

Indexed as

Retinopathy of PrematurityApelinCase-Control StudiesGestational AgeHumansInfantInfant, NewbornInfant, Very Low Birth WeightVascular Endothelial Growth Factor AApelinVascular Endothelial Growth Factor AApelin-13Preterm infantRetinopathy of prematurityVascular endothelial growth factor

Identifiers

PMID35953806
PMCPMC9373384
OpenAlexW4296580997

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.