ArticleBMC geriatrics2022
Associations of multiple chronic disease and depressive symptoms with incident stroke among Chinese middle-aged and elderly adults: a nationwide population-based cohort study.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Efficacy of acupuncture for stroke-associated pneumonia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Associations between continuous health examinations and trajectories of comorbidity of chronic disease: Evidence from a nationwide longitudinal study of middle-aged and older adults in China.Global health research and policy · 2026Article
- Baseline hypertension, adiposity, depressive symptoms, and incident stroke in middle-aged and older Chinese adults: a longitudinal analysis of CHARLS, 2011-2020.BMC public health · 2026Article
- Association of long-term exposure to air pollution with the risk of new-onset pain among middle-aged and older people: a cohort study in China.Clinical rheumatology · 2026Article
- Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population.Annals of medicine · 2025Article
- Analysis of influencing factors on the nutritional status of non-dialysis elderly patients with chronic kidney disease and depression.World journal of psychiatry · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Prevalence and Risk Factors of Type 2 Diabetes Mellitus among Depression Inpatients from 2005 to 2018 in Beijing, China.Health data science · 2025Article
- Inequity in the utilization of the home and community integrated healthcare and daily care services in older adults with limited mobility in China.BMC geriatrics · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Depressive symptoms and all-cause mortality among middle-aged and older people in China and associations with chronic diseases.Frontiers in public health · 2024Article
- Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China.Frontiers in psychiatry · 2023Article
- The role of life satisfaction and living arrangements in the association between chronic disease and depression: a national cross-sectional survey.Frontiers in psychology · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the population aging, multiple chronic diseases, depressive symptoms, and stroke are increasingly common among middle-aged and elderly adults worldwide. This study aimed to explore the independent associations of multiple chronic diseases and depressive symptoms as well as their combination with incident stroke in a prospective cohort of Chinese middle-aged and elderly adults, and to sensitively estimate the association between each type of chronic disease and incident stroke.
methodsThis study used data from the China Health and Retirement Longitudinal Study (CHARLS). A total of 8389 participants meeting the inclusion criteria at baseline (between 2011 and 2012) survey were included, and 7108 eligible participants completed the follow-up survey over 8 years (Wave 4, in 2018). Questionnaire information, physical examination, and clinical and biochemical measurements were collected.
resultsThe mean (SD) age at baseline was 58.5 (± 9.1) years. Multiple chronic disease and depressive symptoms were independently associated with incident stroke. After adjusting for control variables, patients having 1 type of chronic disease and depressive symptoms were at 1.943 (95% CI = 1.166-3.238) times higher risk of incident stroke than those without chronic disease and depressive symptoms, and patients having at least 2 types of chronic diseases and depressive symptoms were at 3.000 (95% CI = 1.846-4.877) times higher risk of incident stroke; the magnitudes of the associations increased by the numbers of having chronic diseases and depressive symptoms. Sensitivity analyses incorporating all five types of chronic disease (i.e., hypertension, dyslipidemia, heart disease, diabetes, and chronic kidney disease) showed that the magnitude of the associations between hypertension and incident stroke was most significant.
conclusionsWe identified significant independent and combined longitudinal associations of multiple chronic diseases and depressive symptoms with incident stroke, and the combined associations reflected a dose-response relationship. The association between hypertension and incident stroke was strongest among the five chronic diseases.
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