Evidence map›Paper›PMID 35953760›Full record

ArticleJournal of Zhejiang University. Science. B2022

HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression.

Cancan Luo, Tiantian Yu, Ken H Young, Li Yu

Open access · greenAbstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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  18. Proapoptotic protein Bim regulates the suppressive function of Treg cells.Journal of Zhejiang University. Science. B · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Cancan LuoDepartment of Hematology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Tiantian YuDepartment of Hematology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Ken H YoungDepartment of Hematopathology, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Li YuDepartment of Hematology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. ndefy02021@ncu.edu.cn.
Nanchang University · CNDuke University · US

Funding

the National Natural Science Foundation of China 81460030 and 81770221
6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of non-Hodgkin's lymphoma. A total of 10%‒15% of DLBCL cases are associated with myelocytomatosis viral oncogene homolog(

Indexed as

Biological PhenomenaLymphoma, Large B-Cell, DiffuseAminopyridinesAnimalsBenzamidesBridged Bicyclo Compounds, HeterocyclicDown-RegulationHistone Deacetylase InhibitorsHumansMiceNeoplasm Recurrence, LocalProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycSulfonamidesTumor Suppressor Protein p53AminopyridinesBCL2 protein, humanBenzamidesBridged Bicyclo Compounds, HeterocyclicHistone Deacetylase InhibitorsN-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamideProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycSulfonamidesTP53 protein, humanTumor Suppressor Protein p53venetoclaxBCL2Diffuse large B-cell lymphoma (DLBCL)Histone deacetylase (HDAC) inhibitorMYCTP53Venetoclax

Identifiers

PMID35953760
PMCPMC9381329
OpenAlexW4291022488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.