ArticleScientific data2022
The Leaf Clinical Trials Corpus: a new resource for query generation from clinical trial eligibility criteria.
Article in Scientific data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Transformer-based relation extraction and concept normalization using an annotated clinical trials corpus.Scientific data · 2026Article
- Artificial intelligence in clinical trial participant recruitment and retention: A scoping review and meta-analysis.Journal of clinical and translational science · 2026Review
- Natural Language Processing in Support of Evidence-based Medicine: A Scoping Review.Findings of ACL. ACL · 2025Article
- Hybrid natural language processing tool for semantic annotation of medical texts in Spanish.BMC bioinformatics · 2025Article
- Article
- AutoCriteria: a generalizable clinical trial eligibility criteria extraction system powered by large language models.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- LeafAI: query generator for clinical cohort discovery rivaling a human programmer.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- A review of research on eligibility criteria for clinical trials.Clinical and experimental medicine · 2023Review
- Named Entity Recognition and Normalization for Alzheimer's Disease Eligibility Criteria.Proceedings. IEEE International Conference on Healthcare Informatics · 2023Article
- Text Classification of Cancer Clinical Trial Eligibility Criteria.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
- Parsable Clinical Trial Eligibility Criteria Representation Using Natural Language Processing.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Identifying cohorts of patients based on eligibility criteria such as medical conditions, procedures, and medication use is critical to recruitment for clinical trials. Such criteria are often most naturally described in free-text, using language familiar to clinicians and researchers. In order to identify potential participants at scale, these criteria must first be translated into queries on clinical databases, which can be labor-intensive and error-prone. Natural language processing (NLP) methods offer a potential means of such conversion into database queries automatically. However they must first be trained and evaluated using corpora which capture clinical trials criteria in sufficient detail. In this paper, we introduce the Leaf Clinical Trials (LCT) corpus, a human-annotated corpus of over 1,000 clinical trial eligibility criteria descriptions using highly granular structured labels capturing a range of biomedical phenomena. We provide details of our schema, annotation process, corpus quality, and statistics. Additionally, we present baseline information extraction results on this corpus as benchmarks for future work.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.