Evidence map›Paper›PMID 35953503›Full record

ArticleScientific reports2022

Protocol and reference values for minimal detectable change of MyotonPRO and ultrasound imaging measurements of muscle and subcutaneous tissue.

Paul E Muckelt, Martin B Warner, Tom Cheliotis-James, Rachel Muckelt, Maria Hastermann, Britt Schoenrock, David Martin, Robert MacGregor, Dieter Blottner, Maria Stokes

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06492057 (ElectroMyoStimulation), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06492057 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

ElectroMyoStimulation (EMS Body Suit) Protocol to Improve Exercise Outcome in Space Missions (EasyMotion-2)

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2025 to 2029Enrolled12ConditionsMuscle Atrophy, Myotonia, Stiffness, SpineArmsElectromyostimulation (EMS), Myoton, Electromyography (EMG), Magnetic Resonance Imaging (MRI), Dynamometry
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Paul E MuckeltSchool of Health Sciences, University of Southampton, Southampton, UK. p.muckelt@soton.ac.uk.
Martin B WarnerSchool of Health Sciences, University of Southampton, Southampton, UK.
Tom Cheliotis-JamesSchool of Health Sciences, University of Southampton, Southampton, UK.
Rachel MuckeltUniversity Centre Sparsholt, Winchester, UK.
Maria HastermannCorporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Experimental and Clinical Research Center (ECRC) & NeuroCure Clinical Research Center (NCRC), Clinical Neuroimmunology, Charité-Universitätsmedizin Berlin, Lindenbergerweg 80, 13125, Berlin, Germany.
Britt SchoenrockNeuroMuscular Group, Center of Space Medicine and Extreme Environments at Charité, Berlin, Germany.
David MartinKBR, Houston, TX, USA.
Robert MacGregorAirbus DS Space Systems, Inc, Houston, TX, USA.
Dieter BlottnerNeuroMuscular Group, Center of Space Medicine and Extreme Environments at Charité, Berlin, Germany.
Maria StokesSchool of Health Sciences, University of Southampton, Southampton, UK.
Charité - Universitätsmedizin Berlin · DEUniversity of Southampton · GBHumboldt-Universität zu Berlin · DEKBR (United States) · USNIHR Southampton Biomedical Research Centre · GBSparsholt College · GBVersus Arthritis · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assessment of muscle health is of paramount importance, as the loss of muscle mass and strength can affect performance. Two non-invasive tools that have been found to be useful in this are the MyotonPRO and rehabilitative ultrasound imaging, both have shown to be reliable in previous studies many of which conducted by the research team. This study aims to determine the reliability of previously unassessed local body structures and to determine their minimal detectable changes (MDC) to support both researchers and clinicians. Twenty healthy participants were recruited to determine the reliability of seven skin positions out of a previously established protocol. Reliability was determined between three independent raters, and day to day reliability was assessed with one rater a week apart. Intraclass Correlation Coefficients (ICC) between raters and between days for tissue stiffness, tone and elasticity range from moderate to excellent (ICC 0.52-0.97), with most good or excellent. ICCs for subcutaneous thickness between days was good or excellent (ICC 0.86-0.91) and moderate to excellent between raters (ICC 0.72-0.96), in muscles it was moderate to excellent between raters and days (ICC 0.71-0.95). The protocol in this study is repeatable with overall good reliability, it also provides established MDC values for several measurement points.

Indexed as

MusclesSubcutaneous TissueHumansReference ValuesReproducibility of ResultsUltrasonography

Identifiers

PMID35953503
PMCPMC9372175
OpenAlexW4291016367

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.