ArticleNature communications2022
Biocatalytic routes to stereo-divergent iridoids.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Antimicrobial and antibiofilm actions of iridoids: a comprehensive mechanistic review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Identification and Optimization of Kratom Strictosidine Pathway Enabled by Yeast Multiplex Engineering.bioRxiv : the preprint server for biology · 2026Article
- Feral Cat Responses to Silver Vine: Implications for Feral Cat Management.Journal of chemical ecology · 2026Article
- Anti-Lipogenic Effects of Iridoid-Rich Lonicera caerulea Berry Extracts in a Cortisol-Stimulated Adipocyte Model.Journal of food science · 2026Article
- Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context.Journal of integrative plant biology · 2026Article
- Enzyformer: a two-stage pretrained model for enzymatic retrosynthesis.Journal of cheminformatics · 2026Article
- Discovery of iridoid cyclase completes the iridoid pathway in asterids.Nature plants · 2025Article
- Plant iridoids: Chemistry, dietary sources and potential health benefits.Food chemistry: X · 2025Review
- Functional evolution and diversification of CYP82D subfamily members have shaped flavonoid diversification in the genus Scutellaria.Plant communications · 2025Article
- Enhancing Substrate Preference of Iridoid Synthase via Focused Polarity-Steric Mutagenesis Scanning.Chem & bio engineering · 2024Article
- Pseudomolecule-scale genome assemblies of Drepanocaryum sewerzowii and Marmoritis complanata.G3 (Bethesda, Md.) · 2024Article
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- Article
- Molecular background of the diverse metabolic profiles in leaves and inflorescences of naked catmint (Frontiers in plant science · 2024Article
- Functional iridoid synthases from iridoid producing and non-producingFrontiers in plant science · 2023Article
- Plants as biofactories for production of the aphid sex pheromone nepetalactone.Physiologia plantarumArticle
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thousands of natural products are derived from the fused cyclopentane-pyran molecular scaffold nepetalactol. These natural products are used in an enormous range of applications that span the agricultural and medical industries. For example, nepetalactone, the oxidized derivative of nepetalactol, is known for its cat attractant properties as well as potential as an insect repellent. Most of these naturally occurring nepetalactol-derived compounds arise from only two out of the eight possible stereoisomers, 7S-cis-trans and 7R-cis-cis nepetalactols. Here we use a combination of naturally occurring and engineered enzymes to produce seven of the eight possible nepetalactol or nepetalactone stereoisomers. These enzymes open the possibilities for biocatalytic production of a broader range of iridoids, providing a versatile system for the diversification of this important natural product scaffold.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.